Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment

Strontium ranelate (SrR) is a relatively new treatment for osteoporosis. In this study we investigated its potential impact on human bone material quality in transiliac bone biopsies from postmenopausal osteoporotic women treated 3 years with calcium and vitamin D plus either 2 g SrR per day or plac...

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Published in:Journal of bone and mineral research 2010-04, Vol.25 (4), p.891-900
Main Authors: Roschger, Paul, Manjubala, Inderchand, Zoeger, Norbert, Meirer, Florian, Simon, Rolf, Li, Chenghao, Fratzl‐Zelman, Nadja, Misof, Barbara M, Paschalis, Eleftherios P, Streli, Christina, Fratzl, Peter, Klaushofer, Klaus
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Density - drug effects
Bone Density Conservation Agents - therapeutic use
bone material quality
Calcium - therapeutic use
Collagen - chemistry
Elastic Modulus
Female
FTIRI
Fundamental and applied biological sciences. Psychology
Humans
Ilium - chemistry
Ilium - pathology
nanoindentation
Organometallic Compounds - analysis
Organometallic Compounds - therapeutic use
osteoporosis
Osteoporosis, Postmenopausal - drug therapy
Osteoporosis, Postmenopausal - pathology
qBEI
Skeleton and joints
SR‐µXRF
strontium ranelate
Thiophenes - analysis
Thiophenes - therapeutic use
Vertebrates: osteoarticular system, musculoskeletal system
Vitamin D - therapeutic use
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Summary:Strontium ranelate (SrR) is a relatively new treatment for osteoporosis. In this study we investigated its potential impact on human bone material quality in transiliac bone biopsies from postmenopausal osteoporotic women treated 3 years with calcium and vitamin D plus either 2 g SrR per day or placebo. Bone mineralization density distribution (BMDD), strontium (Sr) concentration, collagen cross‐link ratio, and indentation modulus were analyzed by quantitative backscattered electron imaging, electron‐induced X‐ray fluorescence analysis, synchrotron radiation induced micro X‐ray fluorescence elemental mapping, Fourier transform infrared imaging, and nanoindentation, respectively. The BMDD of SrR‐treated patients was shifted to higher atomic numbers (Zmean +1.5%, p 
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.091028