Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats

The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological s...

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Bibliographic Details
Published in:Behavioural brain research 2010-06, Vol.210 (1), p.140-142
Main Authors: Vigil, Fabio Antônio Borges, Oliveira-Silva, Ieda de Fátima, Ferreira, Lívia Freire, Pereira, Silvia Rejane Castanheira, Ribeiro, Angela Maria
Format: Article
Language:English
Subjects:
5-HIAA
Analysis of Variance
Animals
Behavioral psychophysiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hydroxyindoleacetic Acid - metabolism
Male
Maze Learning - physiology
Memory Disorders - etiology
Memory Disorders - metabolism
Morris Water Maze
Neuropsychological Tests
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Pyrithiamine
Rats
Rats, Wistar
Serotonin - metabolism
Space Perception - physiology
Spatial learning and memory
Thalamus
Thalamus - metabolism
Thiamine deficiency
Thiamine Deficiency - chemically induced
Thiamine Deficiency - complications
Thiamine Deficiency - metabolism
Time Factors
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Summary:The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2010.02.019