Effect of Adenosine Monophosphate Deaminase-1 C34T Allele on the Requirement for Donor Inotropic Support and on the Incidence of Early Graft Dysfunction After Cardiac Transplantation

The C34T T allele of the adenosine monophosphate deaminase-1 ( AMPD1 ) gene has been associated with improved outcome in patients with cardiac dysfunction. We hypothesized that possession of this allele by donor hearts plays a role in the outcome of cardiac transplantation; 262 cardiac donors and 19...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2009-05, Vol.103 (10), p.1457-1462
Main Authors: Taegtmeyer, Anne B., MRCP, PhD, Breen, Jane B., BSc, Rogers, Paula, BSc, Johnson, Philip H., PhD, Smith, John, PhD, Smolenski, Ryzard T., PhD, Banner, Nicholas R., FRCP, Yacoub, Magdi H., FRS, Barton, Paul J., PhD
Format: Article
Language:English
Subjects:
Adenosine
Adolescent
Adult
Alleles
AMP Deaminase - genetics
Anemia - complications
Biochemistry
Biological and medical sciences
Brain Death
Cardiology
Cardiology. Vascular system
Cardiotonic Agents - administration & dosage
Cardiovascular
Cause of Death
Child
Child, Preschool
Female
Genotype & phenotype
Graft Rejection
Heart
Heart Transplantation
Humans
Infant
Infant, Newborn
Male
Medical sciences
Middle Aged
Multivariate analysis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Survival Rate
Tissue Donors
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The C34T T allele of the adenosine monophosphate deaminase-1 ( AMPD1 ) gene has been associated with improved outcome in patients with cardiac dysfunction. We hypothesized that possession of this allele by donor hearts plays a role in the outcome of cardiac transplantation; 262 cardiac donors and 190 of their recipients were studied. AMPD1 C34T genotype was determined using 5′ exonuclease chemistry. Requirement for inotropic agents before organ donation, 1-year post-transplantation survival, cause of death, and factors known to affect survival after transplantation were also studied. Multiple regression models for factors affecting survival were constructed. A significant yearly increase in frequency of the T allele in donors was noted (0.06 to 0.18 from 1994 to 1999). Donors with the CT or TT genotype required less inotropic support than those with the CC genotype (mean number of inotropes per donor with CT or TT genotype 0.27 compared with 0.47 per donor with CC genotype, n = 206, p = 0.03). Recipients of T-allele–carrying organs showed worse 1-year survival after transplantation (59% vs 79%, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2009.01.360