Transmission-mode direct analysis in real time and desorption electrospray ionization mass spectrometry of insecticide-treated bednets for malaria control

Transmission-mode direct analysis in real time (TM-DART) is presented as an alternative sampling strategy to traditional methods of sample introduction for DART MS analysis. A custom-designed sample holder was fabricated to rapidly and reproducibly position insecticide-treated nets normal to the ion...

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Bibliographic Details
Published in:Analyst (London) 2010-04, Vol.135 (4), p.712-719
Main Authors: Pérez, José J, Harris, Glenn A, Chipuk, Joseph E, Brodbelt, Jennifer S, Green, Michael D, Hampton, Christina Y, Fernández, Facundo M
Format: Article
Language:English
Subjects:
Computer simulation
Desorption
Insecticide-Treated Bednets
Insecticides - analysis
Insecticides - chemistry
Ionization
Malaria - prevention & control
Mass spectra
Nitriles - analysis
Nitriles - chemistry
Permethrin - analysis
Permethrin - chemistry
Pyrethrins - analysis
Pyrethrins - chemistry
Quantitative analysis
Real time
Sampling
Spectrometry, Mass, Electrospray Ionization - instrumentation
Spectrometry, Mass, Electrospray Ionization - methods
Strategy
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Summary:Transmission-mode direct analysis in real time (TM-DART) is presented as an alternative sampling strategy to traditional methods of sample introduction for DART MS analysis. A custom-designed sample holder was fabricated to rapidly and reproducibly position insecticide-treated nets normal to the ionizing metastable gas stream, enabling transmission of desorbed analyte ions through the holder cavity and into the MS. Introduction of the sample at this fixed geometry eliminates the need for optimizing sample position and allows spectra based on factors such as metastable gas temperature and flow to be systematically evaluated. The results presented here, supported by computational fluid dynamic simulations, demonstrate the effects of these factors on the resulting mass spectra and the potential of this sampling strategy to be used for qualitative and quantitative analyses. Transmission-mode desorption electrospray ionization (TM-DESI) experiments on similar insecticide-treated nets were performed for comparison purposes.
ISSN:0003-2654
1364-5528
DOI:10.1039/b924533b