Dedifferentiated liposarcoma of retroperitoneum: spectrum of imaging findings in 15 patients

Abstract Background Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arises in the background of a preexisting well-differentiated liposarcoma. The purpose of this work is to evaluate the spectrum of radiologic appearance of retroperitoneal dedifferentiated liposarcoma with cli...

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Bibliographic Details
Published in:Clinical imaging 2010-05, Vol.34 (3), p.203-210
Main Authors: Hong, Sun Hwa, Kim, Kyeong Ah, Woo, Ok Hee, Park, Cheol Min, Kim, Chul Hwan, Kim, Myeong-Jin, Chung, Jae-Joon, Han, Joon Koo, Rha, Sung Eun
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Dedifferentiated
Dermatology
Female
Humans
Liposarcoma
Liposarcoma - diagnosis
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Pathology
Radiology
Reproducibility of Results
Retroperitoneal Neoplasms - diagnosis
Retroperitoneum
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Abstract Background Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arises in the background of a preexisting well-differentiated liposarcoma. The purpose of this work is to evaluate the spectrum of radiologic appearance of retroperitoneal dedifferentiated liposarcoma with clinicopathologic features. Methods Radiologic images and clinical histories of 15 patients with histologically verified retroperitoneal dedifferentiated liposarcoma were retrospectively studied. Patients included 11 men and 4 women, with mean age of 55.8 years (range, 36–74 years), and they underwent computed tomography (CT) ( n =15) and magnetic resonance imaging (MRI) ( n =5). Results The mean size of the tumor was 22.6 cm with a range of 9.5–38 cm. Both CT and MRI showed well-circumscribed, large round, or lobulated retroperitoneal mass. The appearance of the tumor was classified as follows: Category I, nonfatty component within predominant fatty mass ( n =5); Category II, focal fatty component within large nonfatty mass ( n =6); Category III, well-defined fatty mass and well-defined nonfatty mass ( n =1); Category IV, two masses with predominantly nonfatty component ( n =3). Conclusion Retroperitoneal dedifferentiated liposarcomas present various spectra of imaging findings. While Categories I and III may suggest dedifferentiated liposarcoma, Categories II and IV may appear as other types of liposarcoma or other malignant retroperitoneal tumor.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2009.12.025