DILP‐producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

Summary Dietary restriction extends lifespan in diverse organisms, but the gene regulatory mechanisms and tissues mediating the increased survival are still unclear. Studies in worms and flies have revealed a number of candidate mechanisms, including the target of rapamycin and insulin/IGF‐like sign...

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Bibliographic Details
Published in:Aging cell 2010-06, Vol.9 (3), p.336-346
Main Authors: Broughton, Susan J., Slack, Cathy, Alic, Nazif, Metaxakis, Athanasios, Bass, Timothy M., Driege, Yasmine, Partridge, Linda
Format: Article
Language:English
Subjects:
Aging
Animals
Brain - metabolism
Caenorhabditis elegans
Caloric Restriction
dietary restriction
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Female
Inhibitor of Apoptosis Proteins - genetics
Inhibitor of Apoptosis Proteins - metabolism
insulin‐like peptide
Longevity
Neurosecretion
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Summary:Summary Dietary restriction extends lifespan in diverse organisms, but the gene regulatory mechanisms and tissues mediating the increased survival are still unclear. Studies in worms and flies have revealed a number of candidate mechanisms, including the target of rapamycin and insulin/IGF‐like signalling (IIS) pathways and suggested a specific role for the nervous system in mediating the response. A pair of sensory neurons in Caenorhabditis elegans has been found to specifically mediate DR lifespan extension, but a neuronal focus in the Drosophila nervous system has not yet been identified. We have previously shown that reducing IIS via the partial ablation of median neurosecretory cells in the Drosophila adult brain, which produce three of the seven fly insulin‐like peptides, extends lifespan. Here, we show that these cells are required to mediate the response of lifespan to full feeding in a yeast dilution DR regime and that they appear to do so by mechanisms that involve both altered IIS and other endocrine effects. We also present evidence of an interaction between these mNSCs, nutrition and sleep, further emphasising the functional homology between the DILP‐producing neurosecretory cells in the Drosophila brain and the hypothalamus of mammals in their roles as integration sites of many inputs for the control of lifespan and behaviour.
ISSN:1474-9718
1474-9726
DOI:10.1111/j.1474-9726.2010.00558.x