Prolactin‐secreting adenoma as part of the multiple endocrine neoplasia—type I (MEN‐I) syndrome

Two patients presented with the galactorrhea‐amenorrhea syndrome. One patient had previously had parathyroid hyperplasia and the other an insulinoma. Preoperative evaluation of each patient revealed hyperprolactinemia and radiological evidence of an abnormal sella turcica. Pituitary adenomas were id...

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Bibliographic Details
Published in:Cancer 1979-06, Vol.43 (6), p.2492-2496
Main Authors: Levine, Jon H., Sagel, Julius, Rosebrock, George, Gonzalez, Jorge J., Nair, Raghavan, Rawe, Stephen, Powers, James M.
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Adult
Amenorrhea - etiology
Female
Galactorrhea - etiology
Humans
Multiple Endocrine Neoplasia - metabolism
Multiple Endocrine Neoplasia - pathology
Neoplasms, Multiple Primary - metabolism
Neoplasms, Multiple Primary - pathology
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Pregnancy
Prolactin - metabolism
Syndrome
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Summary:Two patients presented with the galactorrhea‐amenorrhea syndrome. One patient had previously had parathyroid hyperplasia and the other an insulinoma. Preoperative evaluation of each patient revealed hyperprolactinemia and radiological evidence of an abnormal sella turcica. Pituitary adenomas were identified and removed at surgery. Immunostaining techniques confirmed the presence of prolactin‐containing cells in both tumors. We propose that prolactin‐secreting tumors be considered as part of the MEN‐I syndrome, and that patients presenting with the galactorrhea‐amenorrhea syndrome be screened and followed sequentially for evidence of other endocrine neoplasia.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197906)43:6<2492::AID-CNCR2820430647>3.0.CO;2-0