Magnetic resonance diffusion tensor imaging (MRDTI) and tractography in children with septo-optic dysplasia

Background Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of...

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Bibliographic Details
Published in:Pediatric radiology 2010-05, Vol.40 (5), p.708-713
Main Authors: Salmela, Michael B., Cauley, Keith A., Nickerson, Joshua P., Koski, Chris J., Filippi, Christopher G.
Format: Article
Language:English
Subjects:
Brain - pathology
Diffusion Tensor Imaging - methods
Female
Humans
Imaging
Infant
Infant, Newborn
Male
Medicine
Medicine & Public Health
Nerve Fibers, Myelinated - pathology
Neuroradiology
Nuclear Medicine
Oncology
Original Article
Pediatrics
Radiology
Reproducibility of Results
Sensitivity and Specificity
Septo-Optic Dysplasia - pathology
Ultrasound
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Summary:Background Septo-optic dysplasia (SOD) refers to a heterogeneous group of midline brain developmental anomalies, with optic nerve hypoplasia (ONH) being one of the morphologic correlates of the condition. Traditionally, ONH has been diagnosed on fundoscopic exam. Conventional MRI is used in cases of suspected ONH to identify associated brain abnormalities and to compare findings to the fundoscopic exam. Advances in magnetic resonance diffusion tensor imaging (MRDTI) permit in vivo, noninvasive, quantitative characterization of the entire visual pathway at 3.0 T. Objective To investigate the feasibility of MRDTI at 3.0 T in children with SOD to evaluate the entire visual pathway. Materials and methods MRDTI at 3T was performed in two children with SOD and seven age-matched controls. Manual region-of-interest analysis was used to evaluate the tensor metrics of the optic nerves. Deterministic tractography was used to evaluate the tensor metrics of the optic radiations. Results The SOD patients demonstrated a significant decrease in anisotropy and increase in mean diffusivity of the optic nerves and radiations compared to the control subjects. Conclusion This study demonstrates the feasibility of MRDTI to evaluate the entire visual pathway in children, and it demonstrates pre- and post-chiasmatic diffusion tensor abnormalities in SOD patients.
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-009-1478-0