Fungal Homoserine Kinase (thr1Δ) Mutants Are Attenuated in Virulence and Die Rapidly upon Threonine Starvation and Serum Incubation

• Published in: Eukaryotic Cell 2010-05, Vol.9 (5), p.729-737
• Main Authors: Kingsbury, Joanne M, McCusker, John H
• Format: Article
• Language: English
• Subjects: Animals; Calcium - metabolism; Candida albicans; Candida albicans - cytology; Candida albicans - drug effects; Candida albicans - enzymology; Candida albicans - pathogenicity; Chelating Agents - pharmacology; Cryptococcus neoformans; Flucytosine - metabolism; Hydrogen-Ion Concentration - drug effects; Mice; Microbial Viability - drug effects; Mutation - genetics; Phenotype; Phosphotransferases (Alcohol Group Acceptor) - genetics; Saccharomyces cerevisiae; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - drug effects; Saccharomyces cerevisiae - enzymology; Saccharomyces cerevisiae - pathogenicity; Serum - metabolism; Threonine - deficiency; Threonine - pharmacology; Virulence - drug effects
• ISSN: 1535-9778; 1535-9786; 1535-9786
• DOI: 10.1128/EC.00045-10

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