Benefits of moderate weight loss in patients with type 2 diabetes

Weight loss is a primary goal of therapy in overweight patients with type 2 diabetes. This review examines whether positive patient outcomes are observed even after relatively small amounts of weight loss, that is, weight loss being more easily attainable in practice. Clinical studies demonstrate th...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2010-03, Vol.12 (3), p.186-194
Main Author: Fujioka, Ken
Format: Article
Language:English
Subjects:
Appetite Depressants - therapeutic use
blood glucose
Body weight
Cardiovascular diseases
Cardiovascular Diseases - prevention & control
Cardiovascular system
Diabetes
diabetes mellitus
Diabetes mellitus (non-insulin dependent)
diabetes mellitus - type 2
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - therapy
Diabetic Angiopathies - prevention & control
Humans
Obesity - complications
Obesity - therapy
outcome assessment
Overweight
risk assessment
Risk factors
Risk Reduction Behavior
therapeutics
weight gain
weight loss
Weight Loss - physiology
weight-loss agents
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Summary:Weight loss is a primary goal of therapy in overweight patients with type 2 diabetes. This review examines whether positive patient outcomes are observed even after relatively small amounts of weight loss, that is, weight loss being more easily attainable in practice. Clinical studies demonstrate that therapeutic benefit rises with increasing weight loss, but that losses as low as 0.45-4 kg (1-9 lb) have positive effects on metabolic control, cardiovascular risk factors and mortality rates. Even the intention to lose weight, without significant success, can improve outcomes in patients with diabetes, presumably because of the healthy behaviours associated with the attempt. The current data support a continued focus on weight loss, including moderate weight loss, as a key component of good care for overweight patients with type 2 diabetes.
ISSN:1462-8902
1463-1326
DOI:10.1111/j.1463-1326.2009.01155.x