Depression symptoms and cognitive control of emotion cues: a functional magnetic resonance imaging study

Abstract Few studies have examined associations between depressive symptoms and alterations in neural systems that subserve cognitive control. Cognitive control was assessed with an exogenous cueing task using happy, sad, and neutral facial expressions as cues among women with mild to moderate sympt...

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Bibliographic Details
Published in:Neuroscience 2010-04, Vol.167 (1), p.97-103
Main Authors: Beevers, C.G, Clasen, P, Stice, E, Schnyer, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Amygdala - physiopathology
Biological and medical sciences
Brain Mapping
Cognition - physiology
Cues
Depression - physiopathology
emotion processing
Emotions
Facial Expression
Female
fMRI
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging
Neural Pathways - physiopathology
Neurology
Neuropsychological Tests
Parietal Lobe - physiopathology
Prefrontal Cortex - physiopathology
reaction time
ventral lateral PFC
Vertebrates: nervous system and sense organs
Visual Perception - physiology
Young Adult
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Summary:Abstract Few studies have examined associations between depressive symptoms and alterations in neural systems that subserve cognitive control. Cognitive control was assessed with an exogenous cueing task using happy, sad, and neutral facial expressions as cues among women with mild to moderate symptoms of depression and a non-depressed control group while functional magnetic resonance imaging (fMRI) measured brain activity. Amygdala and medial/orbital prefrontal cortex (PFC) response to valid emotion cues did not differ as a function of depression symptoms. However, significant depression group differences were observed when task demands required cognitive control. Participants with elevated depression symptoms showed weaker activation in right and left lateral PFC and parietal regions when shifting attentional focus away from invalid emotion cues. No depression group differences were observed for invalid non-emotional cues. Findings suggest that mild to moderate depression symptoms are associated with altered function in brain regions that mediate cognitive control of emotional information.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2010.01.047