Synthesis of Several Types of Bridged Nucleic Acids

A number of bridged nucleic acids with conformationally locked sugar moiety were synthesized from the readily accessible sugar derivatives. The conformations of the sugar moiety of the bridged nucleic acids (BNAs) are locked to either N-type or S-type sugar puckering. This article summarizes the syn...

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Bibliographic Details
Published in:Chemistry letters 2009, Vol.38 (6), p.512-517
Main Authors: Rahman, S. M. Abdur, Imanishi, Takeshi, Obika, Satoshi
Format: Article
Language:English
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Summary:A number of bridged nucleic acids with conformationally locked sugar moiety were synthesized from the readily accessible sugar derivatives. The conformations of the sugar moiety of the bridged nucleic acids (BNAs) are locked to either N-type or S-type sugar puckering. This article summarizes the synthesis of these nucleic acid analogues.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2009.512