Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey

In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience research 2010-04, Vol.66 (4), p.406-411
Main Authors: Chin, Yo, Sato, Yuki, Mase, Mitsuhito, Kato, Tomomasa, Herculano, Bruno, Sekino, Masaki, Ohsaki, Hiroyuki, Ageyama, Naohide, Ono, Fumiko, Terao, Keiji, Yoshikawa, Yasuhiro, Hisatsune, Tatsuhiro
Format: Article
Language:English
Subjects:
Animals
Brain Infarction - etiology
Brain Infarction - pathology
Brain Infarction - physiopathology
Cerebral Cortex - physiopathology
Cerebral motor pathway
Diffusion Magnetic Resonance Imaging
Diffusion MRI
Efferent Pathways
Functional recovery
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - pathology
Ischemic Attack, Transient - physiopathology
Ischemic injuries
Macaca
Macaca fascicularis
Male
Monkey
Stroke - etiology
Stroke - pathology
Stroke - physiopathology
White matter
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys’ affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2010.01.001