Antidepressant-like effects of 3,6′-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats

• Published in: Neurochemistry international 2010-02, Vol.56 (3), p.461-465
• Main Authors: Hu, Yuan, Liao, Hong-Bo, Dai-Hong, Guo, Liu, Ping, Wang, Yu-Yu, Rahman, Khalid
• Format: Article
• Language: English
• Subjects: 3,6′-Disinapoyl sucrose; Animals; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Appetite Regulation - drug effects; Biological and medical sciences; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Chronic mild stress (CMS); Coumaric Acids - pharmacology; Coumaric Acids - therapeutic use; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; Depressive Disorder - drug therapy; Depressive Disorder - etiology; Depressive Disorder - physiopathology; Disease Models, Animal; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Hippocampus; Hippocampus - drug effects; Hippocampus - physiology; Laminin - genetics; Medical sciences; Nerve Growth Factors - drug effects; Nerve Growth Factors - metabolism; Neural Cell Adhesion Molecules - genetics; Neuronal plasticity; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; Neuropharmacology; Pharmacology. Drug treatments; Polygala; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Rats; Rats, Sprague-Dawley; Reward; RNA, Messenger - drug effects; RNA, Messenger - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology; Stress, Psychological - complications; Stress, Psychological - physiopathology; Sucrose - analogs & derivatives; Sucrose - pharmacology; Sucrose - therapeutic use; Vertebrates: nervous system and sense organs
• ISSN: 0197-0186; 1872-9754
• DOI: 10.1016/j.neuint.2009.12.004

Recent studies suggest that the behavioral effects of chronic antidepressant treatment are mediated by stimulation of hippocampal neuronal plasticity and neurogenesis. The present study was designed to examine the effects of 3,6′-disinapoyl sucrose (DISS), a bioactive component of Polygala tenuifolia Willd, on the expressions of four plasticity-associated genes: cell adhesion molecule L1 (CAM-L1), laminin, cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in hippocampus, all of which are involved in neuronal plasticity and neurite outgrowth. We confirmed that chronic stress in rats caused a reduction in sensitivity to reward (sucrose consumption) and a decrease in mRNA levels of CAM-L1, laminin, and BDNF, together with a decrease in protein levels of phosphorylated CREB and BDNF. Repeated administration of DISS for 21 days at doses of 5, 10 and 20 mg/kg reversed stress-induced alterations in sucrose consumption and these target mRNA and protein levels. In conclusion, increased expressions in the hippocampus of three noradrenergic-regulated plasticity genes and one neurotrophic factor may be one of the molecular and cellular mechanisms underlying the antidepressant action of DISS in chronic mild stress (CMS) rats.