A ‘click chemistry’ approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging

Different thymidine derivatives bearing either an iodoaryl moiety at the 5′ position or a dialkylsilyl group at the 3′ position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated...

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Bibliographic Details
Published in:Tetrahedron letters 2010-02, Vol.51 (8), p.1230-1232
Main Authors: James, Damien, Escudier, Jean-Marc, Amigues, Eric, Schulz, Jürgen, Vitry, Christiane, Bordenave, Thomas, Szlosek-Pinaud, Magali, Fouquet, Eric
Format: Article
Language:English
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Summary:Different thymidine derivatives bearing either an iodoaryl moiety at the 5′ position or a dialkylsilyl group at the 3′ position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.12.120