Functions of notch signaling in the immune system: consensus and controversies

Mammalian genomes encode up to four Notch receptors (Notch1-4) and five Notch ligands of the DSL (Delta/Serrate/Lag-2) family, and Notch signaling controls a wide spectrum of developmental processes. Intrathymic Notch1 signaling is essential for several distinct aspects of early T cell development....

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Bibliographic Details
Published in:Annual review of immunology 2010-01, Vol.28 (1), p.343-365
Main Authors: Yuan, Julie S, Kousis, Philaretos C, Suliman, Sara, Visan, Ioana, Guidos, Cynthia J
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Humans
Immune System - cytology
Immune System - immunology
Immune System - metabolism
Lymphocyte Activation
Polysaccharides - immunology
Receptors, Notch - immunology
Receptors, Notch - metabolism
Signal Transduction
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Summary:Mammalian genomes encode up to four Notch receptors (Notch1-4) and five Notch ligands of the DSL (Delta/Serrate/Lag-2) family, and Notch signaling controls a wide spectrum of developmental processes. Intrathymic Notch1 signaling is essential for several distinct aspects of early T cell development. Notch signaling has also been implicated as a key regulator of peripheral T cell activation and effector cell differentiation, but its functions in these processes remain poorly understood. Notch signaling is dispensable for B cell development in the bone marrow, but it is required to generate the innate-like marginal zone B cell subset in the spleen and may also regulate plasma cell functions. Modification of Notch receptors by fringe glycosyltransferases influences many Notch-dependent aspects of hematopoiesis by altering Notch responsiveness to Delta-like versus Jagged DSL ligands. Here we review recent advances in general aspects of Notch signaling, as well as studies probing Notch functions in these immunological processes.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.021908.132719