Hair cells--beyond the transducer

This review considers the "tween twixt and twain" of hair cell physiology, specifically the signaling elements and membrane conductances which underpin forward and reverse transduction at the input stage of hair cell function and neurotransmitter release at the output stage. Other sections...

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Bibliographic Details
Published in:The Journal of membrane biology 2006-01, Vol.209 (2-3), p.89-118
Main Authors: Housley, G D, Marcotti, W, Navaratnam, D, Yamoah, E N
Format: Article
Language:English
Subjects:
Animals
Hair Cells, Auditory, Inner - physiology
Hair Cells, Auditory, Outer - physiology
Membrane Potentials - physiology
Models, Biological
Potassium Channels - physiology
Receptors, Purinergic - physiology
Signal Transduction - physiology
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Summary:This review considers the "tween twixt and twain" of hair cell physiology, specifically the signaling elements and membrane conductances which underpin forward and reverse transduction at the input stage of hair cell function and neurotransmitter release at the output stage. Other sections of this review series outline the advances which have been made in understanding the molecular physiology of mechanoelectrical transduction and outer hair cell electromotility. Here we outline the contributions of a considerable array of ion channels and receptor signaling pathways that define the biophysical status of the sensory hair cells, contributing to hair cell development and subsequently defining the operational condition of the hair cells across the broad dynamic range of physiological function.
ISSN:0022-2631
1432-1424
DOI:10.1007/s00232-005-0835-7