Templated Ligand Environments for the Selective Incorporation of Different Metals into DNA

Each to his own: DNA templates the formation of bis(terpyridine), bis(phenanthroline), and terpyridine:phenanthroline ligand environments, which strongly bind FeII, CuI, and CuII (see picture), respectively, to generate highly stable metal–DNA complexes. When a metal is placed in the “incorrect” env...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-12, Vol.48 (52), p.9919-9923
Main Authors: Yang, Hua, Rys, Andrzej Z, McLaughlin, Christopher K, Sleiman, Hanadi F
Format: Article
Language:English
Subjects:
Coordination Complexes - chemistry
Copper - chemistry
DNA
DNA - chemistry
helical structures
Iron - chemistry
Ligands
nanostructures
Nanostructures - chemistry
Phenanthrolines - chemistry
Pyridines - chemistry
self-assembly
transition metals
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Summary:Each to his own: DNA templates the formation of bis(terpyridine), bis(phenanthroline), and terpyridine:phenanthroline ligand environments, which strongly bind FeII, CuI, and CuII (see picture), respectively, to generate highly stable metal–DNA complexes. When a metal is placed in the “incorrect” environment, it can spontaneously adjust its redox state, be displaced by another metal, or reorganize the coordination site to create a more favored complex.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200904186