Immunohistochemical study of Langerhans cells in cutaneous lesions of the Jorge Lobo's disease

Jorge Lobo's disease is a chronic infection caused by the fungus Lacazia loboi endemic in South America. The infection is characterized by the appearance of parakeloidal, ulcerated or verrucous nodular or plaque-like cutaneous lesions. The histopathological aspect is characterized by poorly org...

Full description

Saved in:
Bibliographic Details
Published in:Acta tropica 2010-04, Vol.114 (1), p.59-62
Main Authors: Quaresma, Juarez Antonio Simoes, Unger, Debora, Pagliari, Carla, Sotto, Mirian Nacagami, Duarte, Maria Irma Seixas, de Brito, Arival Cardoso
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy
Blastomycoses and paracoccidioidomycosis
Dendritic cells
Dermatomycoses - immunology
Dermatomycoses - microbiology
Dermatomycoses - pathology
Female
General aspects
Human mycoses
Humans
Immunohistochemistry
Immunology
Infectious diseases
Lacazia loboi
Lacaziosis
Langerhans Cells - cytology
Male
Medical sciences
Microscopy
Middle Aged
Mycoses
Onygenales - immunology
Onygenales - isolation & purification
Skin - immunology
Skin - microbiology
Skin - pathology
South America
Tropical mycoses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Jorge Lobo's disease is a chronic infection caused by the fungus Lacazia loboi endemic in South America. The infection is characterized by the appearance of parakeloidal, ulcerated or verrucous nodular or plaque-like cutaneous lesions. The histopathological aspect is characterized by poorly organized granulomas with histiocytes and multinucleated giant cells. Little is known about local immune response in lobomycosis skin lesions. Thirty-three skin biopsies from patients with Jorge Lobo's disease were selected from Ambulatory of Dermatology, UFPA. The control group was constituted by ten biopsies from normal skin. Langerhans cells were identified by immunohistochemistry using anti-CD1a antibody (Serotec). The number of positive cells was statistically analyzed. Langerhans cells were visualized along the epidermis in biopsies from Jorge Lobo's disease and the morphology and the number of Langerhans cells did not differ from normal skin ( p > 0.05). In Jorge Lobo's disease, this cell population probably presents some escape mechanism of the local immune system to evade the antigen presentation by those cells.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2009.12.005