short report: Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10

The levels of interleukin-10 (IL-10) were evaluated in long-term bone marrow (BM) culture supernatants from 54 patients with chronic idiopathic neutropenia (CIN) and 30 healthy volunteers using enzyme-linked immunoabsorbent assay. Cytokine levels were significantly reduced in patients, compared with...

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Bibliographic Details
Published in:British journal of haematology 2006-11, Vol.135 (4), p.570-573
Main Authors: Koumaki, Vasiliki, Damianaki, Athina, Ximeri, Maria, Pontikoglou, Charis, Axioti, Fani, Spanoudakis, Michael, Eliopoulos, George D, Papadaki, Helen A
Format: Article
Language:English
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Summary:The levels of interleukin-10 (IL-10) were evaluated in long-term bone marrow (BM) culture supernatants from 54 patients with chronic idiopathic neutropenia (CIN) and 30 healthy volunteers using enzyme-linked immunoabsorbent assay. Cytokine levels were significantly reduced in patients, compared with controls, and strongly correlated with peripheral blood neutrophil counts. Low levels of supernatant IL-10 were associated with increased values of supernatant IL-1b, tumour necrosis factor-a, IL-6 and transforming growth factor-b sub(1). We suggest that the pro-inflammatory milieu in the BM of CIN patients may be causatively related to the impaired production of IL-10, a cytokine normally displaying strong anti-inflammatory properties.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2006.06345.x