Near-fixation of a Pfmsp1 block 2 allelic variant in genetically diverse Plasmodium falciparum populations across Western Colombia

Assessment of the genetic diversity of Plasmodium falciparum in 110 Colombian isolates revealed that nearly all the parasites in the 97 isolates collected in endemic regions west of the Andes shared the same Pfmsp1 block 2 MAD20-type allelic variant, despite showing high diversity for other genetica...

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Bibliographic Details
Published in:Acta tropica 2010-04, Vol.114 (1), p.67-70
Main Authors: Jiménez, Judy Natalia, Snounou, Georges, Letourneur, Frank, Rénia, Laurent, Vélez, Iván D., Muskus, Carlos E.
Format: Article
Language:English
Subjects:
Alleles
Animals
Biological and medical sciences
Colombia
DNA, Protozoan - chemistry
DNA, Protozoan - genetics
Gene Frequency
General aspects
Genetic diversity
Genetic Variation
Genotype
Glutamate rich protein
Humans
Malaria, Falciparum - parasitology
Medical sciences
Merozoite surface protein 1
Merozoite Surface Protein 1 - genetics
Merozoite surface protein 2
Molecular Sequence Data
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium falciparum - isolation & purification
Sequence Analysis, DNA
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Summary:Assessment of the genetic diversity of Plasmodium falciparum in 110 Colombian isolates revealed that nearly all the parasites in the 97 isolates collected in endemic regions west of the Andes shared the same Pfmsp1 block 2 MAD20-type allelic variant, despite showing high diversity for other genetical markers. Analysis of published data indicated that the prevalence of this allelic variant of a major vaccine candidate antigen was already dominant since 1998. This phenomenon, which had not been hitherto recorded for a malaria blood stage antigen, is of biological and immunological interest but remains unexplained.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2009.12.009