Visuo-motor and cognitive procedural learning in children with basal ganglia pathology

We investigated procedural learning in 18 children with basal ganglia (BG) lesions or dysfunctions of various aetiologies, using a visuo-motor learning test, the Serial Reaction Time (SRT) task, and a cognitive learning test, the Probabilistic Classification Learning (PCL) task. We compared patients...

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Bibliographic Details
Published in:Neuropsychologia 2010-06, Vol.48 (7), p.2009-2017
Main Authors: Mayor-Dubois, C., Maeder, P., Zesiger, P., Roulet-Perez, E.
Format: Article
Language:English
Subjects:
Adolescent
Basal Ganglia Diseases - complications
Basal Ganglia Diseases - pathology
Basal ganglia pathology
Biological and medical sciences
Brain Mapping
Child
Child clinical studies
Children
Classification
Cognition Disorders - etiology
Comparative Analysis
Female
Humans
Knowledge
Learning - physiology
Learning Processes
Male
Medical sciences
Neurological Impairments
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Pathology
Patients
Probabilistic Classification Learning
Probability Learning
Psychology. Psychoanalysis. Psychiatry
Psychomotor Skills
Psychopathology. Psychiatry
Reaction Time
Reaction Time - physiology
Serial Learning
Serial Reaction Time
Task Analysis
Visual Perception
Visual Perception - physiology
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Summary:We investigated procedural learning in 18 children with basal ganglia (BG) lesions or dysfunctions of various aetiologies, using a visuo-motor learning test, the Serial Reaction Time (SRT) task, and a cognitive learning test, the Probabilistic Classification Learning (PCL) task. We compared patients with early (6 years old, n = 7) or progressive disorder (idiopathic dystonia, n = 2). All patients showed deficits in both visuo-motor and cognitive domains, except those with idiopathic dystonia, who displayed preserved classification learning skills. Impairments seem to be independent from the age of onset of pathology. As far as we know, this study is the first to investigate motor and cognitive procedural learning in children with BG damage. Procedural impairments were documented whatever the aetiology of the BG damage/dysfunction and time of pathology onset, thus supporting the claim of very early skill learning development and lack of plasticity in case of damage.
ISSN:0028-3932
1873-3514
DOI:10.1016/j.neuropsychologia.2010.03.022