PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection

Dysfunctional virus‐specific T cells are a hallmark of many chronic viral infections. Recent studies have implicated the inhibitory PD‐1/PD‐L1 pathway with the functional impairment of T cells. In this respect, we will review the latest research on PD‐1/PD‐L1 pathway and T‐cell exhaustion in the con...

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Bibliographic Details
Published in:Journal of viral hepatitis 2010-07, Vol.17 (7), p.453-458
Main Authors: Watanabe, T., Bertoletti, A., Tanoto, T. A.
Format: Article
Language:English
Subjects:
Antigens, CD - physiology
Apoptosis Regulatory Proteins - physiology
B7-H1 Antigen
HBV
HCV
Hepatitis B, Chronic - immunology
Hepatitis C, Chronic - immunology
Humans
Lymphocyte Depletion
Models, Biological
PD-1
PD-L1
Programmed Cell Death 1 Receptor
T cell
T-Lymphocytes - immunology
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Summary:Dysfunctional virus‐specific T cells are a hallmark of many chronic viral infections. Recent studies have implicated the inhibitory PD‐1/PD‐L1 pathway with the functional impairment of T cells. In this respect, we will review the latest research on PD‐1/PD‐L1 pathway and T‐cell exhaustion in the context of human chronic hepatitis B and C virus infections. We will also discuss the therapeutic potential of PD‐1 blockade and how it may be enhanced through the modulation of other co‐stimulatory/inhibitory pathways.
ISSN:1352-0504
1365-2893
DOI:10.1111/j.1365-2893.2010.01313.x