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HIV-Unrelated Benign Lymphoepithelial Cyst of the Parotid Glands Containing Lymphoepithelial Lesion—Like Structures: A Report of 3 Cases
Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structu...
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| Published in: | International journal of surgical pathology 2009-12, Vol.17 (6), p.421-425 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c368t-cef6acea8786ae73b176eae06df13c80fc3d468b3a261ea9024f60bad642b4cd3 |
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| cites | cdi_FETCH-LOGICAL-c368t-cef6acea8786ae73b176eae06df13c80fc3d468b3a261ea9024f60bad642b4cd3 |
| container_end_page | 425 |
| container_issue | 6 |
| container_start_page | 421 |
| container_title | International journal of surgical pathology |
| container_volume | 17 |
| creator | Kojima, Masaru Nakamura, Naoya Matsuda, Hazuki Kaba, Sadayuki Itoh, Hideaki Masawa, Nobuhide |
| description | Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically, 3 lesions were characterized by cuboidal epithelial-lined, cystic spaces, numerous lymphoid follicles, and dense lymphoplasmacytoid infiltrate. Moreover, small lymphocytes invaded the epithelial clusters forming LeL-like structures. Histological findings of 3 lesions resembled marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. However, staining with CD3, CD5, and CD20 demonstrated the mixed nature of small lymphocytes invading the epithelial clusters (LeLlike structures). Moreover, there were no CD43+ B-lymphocytes in any of the cases. The polytypic nature of B-lymphocytes was demonstrated by immunohistochemistry and polymerase chain reaction. The 3 cases indicate that HIV-unrelated BLC should be added to the differential diagnosis of MALT-type lymphoma involving the parotid glands. |
| doi_str_mv | 10.1177/1066896908328575 |
| format | article |
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Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically, 3 lesions were characterized by cuboidal epithelial-lined, cystic spaces, numerous lymphoid follicles, and dense lymphoplasmacytoid infiltrate. Moreover, small lymphocytes invaded the epithelial clusters forming LeL-like structures. Histological findings of 3 lesions resembled marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. However, staining with CD3, CD5, and CD20 demonstrated the mixed nature of small lymphocytes invading the epithelial clusters (LeLlike structures). Moreover, there were no CD43+ B-lymphocytes in any of the cases. The polytypic nature of B-lymphocytes was demonstrated by immunohistochemistry and polymerase chain reaction. The 3 cases indicate that HIV-unrelated BLC should be added to the differential diagnosis of MALT-type lymphoma involving the parotid glands.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896908328575</identifier><identifier>PMID: 19064590</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Biomarkers - metabolism ; Cysts - metabolism ; Cysts - pathology ; Cysts - surgery ; Diagnosis, Differential ; Epithelial Cells - metabolism ; Epithelial Cells - pathology ; Female ; HIV Infections - pathology ; Human immunodeficiency virus 1 ; Humans ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Lymphoma, B-Cell, Marginal Zone - diagnosis ; Lymphoproliferative Disorders - metabolism ; Lymphoproliferative Disorders - pathology ; Lymphoproliferative Disorders - surgery ; Male ; Middle Aged ; Parotid Diseases - metabolism ; Parotid Diseases - pathology ; Parotid Diseases - surgery ; Parotid Gland - metabolism ; Parotid Gland - pathology ; Parotid Gland - surgery ; Treatment Outcome</subject><ispartof>International journal of surgical pathology, 2009-12, Vol.17 (6), p.421-425</ispartof><rights>2009 The Author(s)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-cef6acea8786ae73b176eae06df13c80fc3d468b3a261ea9024f60bad642b4cd3</citedby><cites>FETCH-LOGICAL-c368t-cef6acea8786ae73b176eae06df13c80fc3d468b3a261ea9024f60bad642b4cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904,79110</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19064590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojima, Masaru</creatorcontrib><creatorcontrib>Nakamura, Naoya</creatorcontrib><creatorcontrib>Matsuda, Hazuki</creatorcontrib><creatorcontrib>Kaba, Sadayuki</creatorcontrib><creatorcontrib>Itoh, Hideaki</creatorcontrib><creatorcontrib>Masawa, Nobuhide</creatorcontrib><title>HIV-Unrelated Benign Lymphoepithelial Cyst of the Parotid Glands Containing Lymphoepithelial Lesion—Like Structures: A Report of 3 Cases</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically, 3 lesions were characterized by cuboidal epithelial-lined, cystic spaces, numerous lymphoid follicles, and dense lymphoplasmacytoid infiltrate. Moreover, small lymphocytes invaded the epithelial clusters forming LeL-like structures. Histological findings of 3 lesions resembled marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. However, staining with CD3, CD5, and CD20 demonstrated the mixed nature of small lymphocytes invading the epithelial clusters (LeLlike structures). Moreover, there were no CD43+ B-lymphocytes in any of the cases. The polytypic nature of B-lymphocytes was demonstrated by immunohistochemistry and polymerase chain reaction. The 3 cases indicate that HIV-unrelated BLC should be added to the differential diagnosis of MALT-type lymphoma involving the parotid glands.</description><subject>Adult</subject><subject>Biomarkers - metabolism</subject><subject>Cysts - metabolism</subject><subject>Cysts - pathology</subject><subject>Cysts - surgery</subject><subject>Diagnosis, Differential</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>HIV Infections - pathology</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Lymphoma, B-Cell, Marginal Zone - diagnosis</subject><subject>Lymphoproliferative Disorders - metabolism</subject><subject>Lymphoproliferative Disorders - pathology</subject><subject>Lymphoproliferative Disorders - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parotid Diseases - metabolism</subject><subject>Parotid Diseases - pathology</subject><subject>Parotid Diseases - surgery</subject><subject>Parotid Gland - metabolism</subject><subject>Parotid Gland - pathology</subject><subject>Parotid Gland - surgery</subject><subject>Treatment Outcome</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkT1P3TAUhq0KVCjt3gl5Y0rrrzhJN4goIEUC0dI1cpyTiyHXDrYz3K0zM7-QX4LpvRJSEWKyrfO8j3T8IvSVkm-UFsV3SqQsK1mRkrMyL_IPaJdWgmRMyHwr3dM4e57voE8h3BBCmGT0I9qhFZEir8guuj89-5NdWQ-jitDjI7BmYXGzWk7XDiYTr2E0asT1KkTsBpze-EJ5F02PT0Zl-4BrZ6My1tjF61gDwTj7-PehMbeAf0U_6zh7CD_wIb6Eyfl_Uo5rFSB8RtuDGgN82Zx76Orn8e_6NGvOT87qwybTXJYx0zBIpUGVRSkVFLyjhQQFRPYD5bokg-a9kGXHFZMUVEWYGCTpVC8F64Tu-R46WHsn7-5mCLFdmqBhTOuAm0NbCElZnrPqfZILmictSSRZk9q7EDwM7eTNUvlVS0n7XFX7f1Upsr-Rz90S-pfAppsEZGsgqAW0N272Nn3L28InF3eeJA</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Kojima, Masaru</creator><creator>Nakamura, Naoya</creator><creator>Matsuda, Hazuki</creator><creator>Kaba, Sadayuki</creator><creator>Itoh, Hideaki</creator><creator>Masawa, Nobuhide</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>200912</creationdate><title>HIV-Unrelated Benign Lymphoepithelial Cyst of the Parotid Glands Containing Lymphoepithelial Lesion—Like Structures: A Report of 3 Cases</title><author>Kojima, Masaru ; 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Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically, 3 lesions were characterized by cuboidal epithelial-lined, cystic spaces, numerous lymphoid follicles, and dense lymphoplasmacytoid infiltrate. Moreover, small lymphocytes invaded the epithelial clusters forming LeL-like structures. Histological findings of 3 lesions resembled marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. However, staining with CD3, CD5, and CD20 demonstrated the mixed nature of small lymphocytes invading the epithelial clusters (LeLlike structures). Moreover, there were no CD43+ B-lymphocytes in any of the cases. The polytypic nature of B-lymphocytes was demonstrated by immunohistochemistry and polymerase chain reaction. 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| ispartof | International journal of surgical pathology, 2009-12, Vol.17 (6), p.421-425 |
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| source | SAGE |
| subjects | Adult Biomarkers - metabolism Cysts - metabolism Cysts - pathology Cysts - surgery Diagnosis, Differential Epithelial Cells - metabolism Epithelial Cells - pathology Female HIV Infections - pathology Human immunodeficiency virus 1 Humans Lymphocytes - metabolism Lymphocytes - pathology Lymphoma, B-Cell, Marginal Zone - diagnosis Lymphoproliferative Disorders - metabolism Lymphoproliferative Disorders - pathology Lymphoproliferative Disorders - surgery Male Middle Aged Parotid Diseases - metabolism Parotid Diseases - pathology Parotid Diseases - surgery Parotid Gland - metabolism Parotid Gland - pathology Parotid Gland - surgery Treatment Outcome |
| title | HIV-Unrelated Benign Lymphoepithelial Cyst of the Parotid Glands Containing Lymphoepithelial Lesion—Like Structures: A Report of 3 Cases |
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