Comparison of Neointimal Coverage of Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents Using Optical Coherence Tomography at 9 Months After Implantation

• Published in: Circulation Journal 2010, Vol.74(2), pp.320-326
• Main Authors: Kim, Jin-Sun, Kim, Jung-Sun, Kim, Tae Hoon, Fan, Chunyu, Lee, Jung Myung, Kim, Woong, Ko, Young-Guk, Choi, Donghoon, Hong, Myeong-Ki, Jang, Yangsoo
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - instrumentation; Cardiovascular Agents - administration & dosage; Coronary Angiography; Coronary Artery Disease - pathology; Coronary Artery Disease - therapy; Coronary Vessels - pathology; Drug-eluting stent; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Optical coherence; Paclitaxel; Paclitaxel - administration & dosage; Prosthesis Design; Registries; Sirolimus; Sirolimus - administration & dosage; Thrombosis - etiology; Thrombosis - pathology; Time Factors; Tomography; Tomography, Optical Coherence; Treatment Outcome; Tunica Intima - pathology
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-09-0546

Background: The differences between using Sirolimus-eluting stents (SESs) and Paclitaxel-eluting stents (PESs) in the vascular response at 9 months after implantation were examined with optical coherence tomography (OCT). Methods and Results: OCT was carried out in 33 SESs [33 patients, 19 with acute coronary syndrome (ACS) and 14 with stable angina pectoris (SAP)] and 27 PESs (27 patients, 15 with ACS and 12 with SAP) at 9 months after stent implantation. Stent strut coverage and apposition at each strut were evaluated. The frequency of uncovered struts was significantly higher in SES (12.5±15.2 vs 4.9±7.9 %, P=0.01). The incidence of complete covered stents with neointima was 9.1% (3/33) in SES and 29.6% (8/27) in PES (P=0.05). The pattern of neointima in PES was more heterogeneous than that in SES (1.3±0.5 for SES vs 2.0±0.6 for PES, P