Assessing the toxicological significance of ejaculatory plugs as a clinical observation in rat toxicology studies: CNS-mediated increases in plug production vs. gustatory-mediated decreases in plug consumption

Spontaneous ejaculation has been reported in a variety of mammalian species and may occur either as a result of pharmacological treatment or as a component of the daily behavior of normal, untreated animals. Infrequently, increased numbers of spontaneous ejaculatory plugs have been reported among th...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-06, Vol.29 (3), p.271-278
Main Authors: Reynolds, Vincent L., Stump, Donald G., Holson, Joseph F.
Format: Article
Language:English
Subjects:
ACTH
Animals
Biological and medical sciences
Copulatory plugs
Ejaculation
Ejaculation - physiology
Ejaculatory plugs
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Male
Medical sciences
MSH
Observation
para-Chlorophenylalanine
Physiological Phenomena
Rats
Reproductive toxicity testing
Semen
Seminal plugs
Teratology. Teratogens
Toxicology
Vaginal plugs
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Summary:Spontaneous ejaculation has been reported in a variety of mammalian species and may occur either as a result of pharmacological treatment or as a component of the daily behavior of normal, untreated animals. Infrequently, increased numbers of spontaneous ejaculatory plugs have been reported among the clinical signs in rat toxicology studies. This mini-review presents an overview on the presence of ejaculatory plugs in rodents and provides recommendations to consider when attempting to understand the toxicological significance of increased numbers of ejaculatory plugs in rat toxicology studies.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2010.02.003