Disease transmission model for community-associated Clostridium difficile infection

Participating researchers and public health personnel at a Canadian workshop in 2007, noted considerable gaps in current understanding of community-associated Clostridium difficile infection (CA-CDI), specifically infection sources and risk factors. A disease transmission model for CA-CDI was reques...

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Bibliographic Details
Published in:Epidemiology and infection 2010-06, Vol.138 (6), p.907-914
Main Authors: OTTEN, A. M., REID-SMITH, R. J., FAZIL, A., WEESE, J. S.
Format: Article
Language:English
Subjects:
Animal hospitals
Animals
Bacteriology
Biological and medical sciences
Clostridium difficile
Clostridium Infections - epidemiology
Clostridium Infections - transmission
Community-Acquired Infections - epidemiology
Community-Acquired Infections - transmission
Diarrhea
Disease models
Disease transmission
Disease Vectors
Dogs
Epidemiology
Fundamental and applied biological sciences. Psychology
Hospitals
Humans
Infections
infectious disease epidemiology
Infectious diseases
Inflammatory bowel disease
Microbiology
Miscellaneous
Modelling and methods
Models, Biological
Public health
Relapse
Risk Assessment
Risk Factors
transmission
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Summary:Participating researchers and public health personnel at a Canadian workshop in 2007, noted considerable gaps in current understanding of community-associated Clostridium difficile infection (CA-CDI), specifically infection sources and risk factors. A disease transmission model for CA-CDI was requested as an initial step towards a risk assessment, to analyse infection sources and risk factors, addressing priority research areas. The developed model contains eight infection states (susceptible, gastrointestinal exposure, colonized, diseased, deceased, clinically resolved colonized, relapse diseased, and cleared) and notes directional transfers between the states. Most published research used focused on hospital-associated C. difficile infection (HA-CDI) and further studies are needed to substantiate the use of HA-CDI knowledge in the transmission of CA-CDI. The aim was to provide a consistent framework for researchers, and provide a theoretical basis for future quantitative risk assessment of CA-CDI.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268809991646