Diagnostic Accuracy of a Rapid Real-Time Polymerase Chain Reaction Assay for Universal Intrapartum Group B Streptococcus Screening

Background. Intrapartum antibiotic prophylaxis is currently given to mothers who test positive for group B streptococcus (GBS) by antenatal culture-based screening, with a risk-based approach for cases with an unknown GBS status. A rapid real-time polymerase chain reaction (PCR) assay for the detect...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-08, Vol.49 (3), p.417-423
Main Authors: El Helali, Najoua, Nguyen, Jean-Claude, Ly, Aïcha, Giovangrandi, Yves, Trinquart, Ludovic
Format: Article
Language:English
Subjects:
Accuracy
Antibiotics
Articles and Commentaries
Bacteria
Bacterial diseases
Biological and medical sciences
Biopolymers
Female
France
Human bacterial diseases
Humans
Infant, Newborn
Infections
Infectious diseases
Mass Screening - methods
Medical diagnosis
Medical sciences
Neonatal diseases
Neonatal screening
Pharmacology
Polymerase chain reaction
Polymerase Chain Reaction - methods
Predictive Value of Tests
Predisposing factors
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Preventive medicine
Prospective Studies
Real time
Screening tests
Sensitivity and Specificity
Specimens
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcal Infections - diagnosis
Streptococcus
Streptococcus agalactiae
Streptococcus agalactiae - isolation & purification
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Summary:Background. Intrapartum antibiotic prophylaxis is currently given to mothers who test positive for group B streptococcus (GBS) by antenatal culture-based screening, with a risk-based approach for cases with an unknown GBS status. A rapid real-time polymerase chain reaction (PCR) assay for the detection of GBS became available recently, making intrapartum screening possible. We aimed to assess its diagnostic accuracy and to compare it with antenatal screening. Methods. We conducted a prospective study in a French hospital. All pregnant women giving birth at the maternity ward were considered for inclusion, except those with planned cesarean delivery, with delivery at
ISSN:1058-4838
1537-6591
DOI:10.1086/600303