Analysis of seventeen Y-chromosome STR loci in the Cape Muslim population of South Africa

Abstract Two Y-STR genotyping systems were evaluated for usefulness in forensic casework in the Cape Muslim population of South Africa. Samples were collected from 105 males, and genotyped for 17 loci amplified in two multiplexes. Allele and haplotype frequencies were determined for nine Y-STR loci...

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Bibliographic Details
Published in:Legal medicine (Tokyo, Japan) Japan), 2010-01, Vol.12 (1), p.42-45
Main Authors: Cloete, Kevin, Ehrenreich, Liezle, D’Amato, María Eugenia, Leat, Neil, Davison, Sean, Benjeddou, Mongi
Format: Article
Language:English
Subjects:
Alleles
Cape Muslim community
Chromosomes, Human, Y
DNA - analysis
Forensic Genetics - methods
Genetic Loci
Haplotypes
Humans
Internal Medicine
Male
Minimal haplotype
Mouth Mucosa - diagnostic imaging
Population data
South Africa
Tandem Repeat Sequences
Ultrasonography
Y-STR
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Summary:Abstract Two Y-STR genotyping systems were evaluated for usefulness in forensic casework in the Cape Muslim population of South Africa. Samples were collected from 105 males, and genotyped for 17 loci amplified in two multiplexes. Allele and haplotype frequencies were determined for nine Y-STR loci used to define the minimal haplotype (DYS19, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393, and the duplicated locus DYS385) amplified in one multiplex, as well as for eight widely used loci amplified in a second multiplex and consisting of DYS449, DYS481, DYS518, DYS557, DYS570, DYS607, DYS612 and DYS614. When analysing the samples for all the loci, 104 unique haplotypes were obtained, and the discrimination capacity was 0.990. When considering only the nine Y-STRs included in the minimal haplotype, 91 unique haplotypes were obtained, and the discrimination capacity was 0.866. In the case of the remaining eight Y-STR loci, values of 97 and 0.924 were obtained, respectively.
ISSN:1344-6223
1873-4162
DOI:10.1016/j.legalmed.2009.10.001