Antitumor activity of the immunomodulatory lead Cumaside

A new immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless...

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Bibliographic Details
Published in:International immunopharmacology 2010-06, Vol.10 (6), p.648-654
Main Authors: Aminin, D.L., Chaykina, E.L., Agafonova, I.G., Avilov, S.A., Kalinin, V.I., Stonik, V.A.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antitumor activity
Carcinoma, Ehrlich Tumor - drug therapy
Cell Line, Tumor
Cholesterol - analogs & derivatives
Cholesterol - chemistry
Cholesterol - therapeutic use
Cucumaria japonica
Cucumariosides
Cumaside
Echinoidea
Female
Fluorouracil - therapeutic use
Glycosides - chemistry
Glycosides - therapeutic use
Holothurioidea
Immunologic Factors - chemistry
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Immunomodulatory activity
Male
Mice
Saponins - therapeutic use
Sea cucumbers
Triterpenes - chemistry
Triterpenes - therapeutic use
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Summary:A new immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless Cumaside has an antitumor activity against different forms of experimental mouse Ehrlich carcinoma in vivo both independently and in combination with cytostatics. The highest effect occurs at a treatment once a day for 7 days before the tumor inoculation followed by Cumaside treatment once a day for 7 days. Prophylactic treatment with Cumaside and subsequent therapeutic application of 5-fluorouracil suppressed the tumor growth by 43%.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2010.03.003