Understanding inflammatory pain: ion channels contributing to acute and chronic nociception

Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the mole...

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Bibliographic Details
Published in:Pflügers Archiv 2010-04, Vol.459 (5), p.657-669
Main Authors: Linley, John E., Rose, Kirstin, Ooi, Lezanne, Gamper, Nikita
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chronic Disease
Human Physiology
Humans
Inflammation - metabolism
Invited Review
Molecular Medicine
Neurosciences
Nociceptors - physiology
Pain - metabolism
Receptors
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Summary:Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-010-0784-6