Spontaneous Aortitis in the Balb/c Mouse

We examined whether high incidence rates (18%–56%) of inflammation in the root of the aorta detected in a Balb/c mouse model for hind limb ischemia were related to the surgical procedure. Twenty mice underwent ligation of the femoral artery; incidences of aortic root inflammation were compared to th...

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Bibliographic Details
Published in:Toxicologic pathology 2009-08, Vol.37 (5), p.667-671
Main Authors: Ramot, Yuval, Manno, Rose Anna, Okazaki, Yoshimasa, Krakovsky, Michael, Lamensdorf, Itschak, Meiron, Moran, Toren, Amir, Zehavi-Goldstein, Efrat, Vezzali, Enrico, Nyska, Abraham
Format: Article
Language:English
Subjects:
Animals
Aorta - pathology
Aortitis - blood
Aortitis - metabolism
Aortitis - pathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cytokines - blood
Disease Models, Animal
Diseases of the aorta
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Femoral Artery - surgery
Hindlimb - blood supply
Histocytochemistry
Ischemia - blood
Ischemia - etiology
Ischemia - metabolism
Ischemia - pathology
Male
Medical sciences
Mice
Mice, Inbred BALB C
Toxicology
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Summary:We examined whether high incidence rates (18%–56%) of inflammation in the root of the aorta detected in a Balb/c mouse model for hind limb ischemia were related to the surgical procedure. Twenty mice underwent ligation of the femoral artery; incidences of aortic root inflammation were compared to those observed in controls. We used a multiple-section sampling method to increase the sensitivity of the diagnostic rates. Although a cumulative incidence of 12.5% was found, no difference was seen in the overall incidence rates between the control and the surgically treated groups. Evaluation of blood levels of inflammatory cytokines showed that ligation of the femoral artery produced higher levels of interleukin-6 in the surgically transected group of mice. The development of spontaneous arteritis in this strain must be considered in future studies.
ISSN:0192-6233
1533-1601
DOI:10.1177/0192623309338384