Microdevice for the isolation and enumeration of cancer cells from blood

Cancer metastasis is the main attribute to cancer-related deaths. Furthermore, clinical reports have shown a strong correlation between the disease development and number of circulating tumor cells (CTCs) in the peripheral blood of cancer patients. Here, we present a label-free microdevice capable o...

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Bibliographic Details
Published in:Biomedical microdevices 2009-08, Vol.11 (4), p.883-892
Main Authors: Tan, Swee Jin, Yobas, Levent, Lee, Gabriel Yew Hoe, Ong, Choon Nam, Lim, Chwee Teck
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - pathology
Biological and Medical Physics
Biomedical engineering
Biomedical Engineering and Bioengineering
Biophysics
Blood
Cancer
Cell Line, Tumor
Cell Separation - instrumentation
Cell Separation - methods
Cell Survival
Cellular biology
Engineering
Engineering Fluid Dynamics
Fluid dynamics
Humans
Metastasis
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
Nanotechnology
Neoplasm Metastasis
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Summary:Cancer metastasis is the main attribute to cancer-related deaths. Furthermore, clinical reports have shown a strong correlation between the disease development and number of circulating tumor cells (CTCs) in the peripheral blood of cancer patients. Here, we present a label-free microdevice capable of isolating cancer cells from whole blood via their distinctively different physical properties such as deformability and size. The isolation efficiency is at least 80% for tests performed on breast and colon cancer cells. Viable isolated cells are also obtained which may give further insights to the understanding of the metastatic process. Contrasting with conventional biochemical techniques, the uniqueness of this microdevice lies in the mechanistic and efficient means of isolating viable cancer cells in blood. The microdevice has the potential to be used for routine monitoring of cancer development and cancer therapy in a clinical setting.
ISSN:1387-2176
1572-8781
DOI:10.1007/s10544-009-9305-9