Formation of biodegradable microcapsules utilizing 3D, selectively surface-modified PDMS microfluidic devices

We have successfully demonstrated the formation of biodegradable microcapsules utilizing PDMS double-emulsification devices. Specially designed 3D PDMS microchannels with surfaces selectively modified by a self-aligned photografting process are employed to generate monodisperse water-in-organic-solv...

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Bibliographic Details
Published in:Biomedical microdevices 2010-02, Vol.12 (1), p.125-133
Main Authors: Liao, Chung-Yu, Su, Yu-Chuan
Format: Article
Language:English
Subjects:
Absorbable Implants
Biodegradable materials
Biological and Medical Physics
Biomedical engineering
Biomedical Engineering and Bioengineering
Biophysics
Capsules - chemical synthesis
Delayed-Action Preparations - chemical synthesis
Dimethylpolysiloxanes - chemistry
Drug Compounding - instrumentation
Drug Compounding - methods
Drug delivery systems
Engineering
Engineering Fluid Dynamics
Equipment Design
Equipment Failure Analysis
Flow control
Fluid dynamics
Materials Testing
Microfluidic Analytical Techniques - instrumentation
Nanoparticles
Nanotechnology
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Summary:We have successfully demonstrated the formation of biodegradable microcapsules utilizing PDMS double-emulsification devices. Specially designed 3D PDMS microchannels with surfaces selectively modified by a self-aligned photografting process are employed to generate monodisperse water-in-organic-solvent-in-water (W/O/W) emulsions in a controlled manner. Mainly by varying the outer and inner fluid flow-rates, the dimensions of resulting double emulsions can be adjusted as desired. Meanwhile, biodegradable materials are dissolved in the middle organic solvent (in this work ethyl acetate is used), and solidified into microcapsules once the solvent is extracted. In the prototype demonstration, microcapsules made up of poly(L-lactic acid), trilaurin, and phosphocholine were successfully fabricated. In addition, it was also demonstrated that γ-Fe₂O₃ nanoparticles can be simultaneously embedded into the microcapsules, which consequently become responsive to electromagnetic stimulation. As such, the presented PDMS microfluidic devices could potentially serve as versatile encapsulation apparatus, and the fabricated biodegradable microcapsules could function as controlled delivery systems, which are desired for a variety of biological and pharmaceutical applications.
ISSN:1387-2176
1572-8781
DOI:10.1007/s10544-009-9367-8