Image-based screening: a technology in transition

Image-based screening (IBS) has proven itself with whole-well assays in which throughput and assay miniaturization are priorities. Recent interest, however, has centered upon the use of automated imaging technology to conduct assays at subcellular resolution. These in vitro assays have the potential...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in biotechnology 2005-02, Vol.16 (1), p.41-48
Main Author: Ramm, Peter
Format: Article
Language:English
Subjects:
Bioinformatics
Biotechnology - methods
Biotechnology - trends
Data processing
Drug discovery
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - trends
Image Interpretation, Computer-Assisted - methods
imaging
Microarray Analysis - methods
Microarray Analysis - trends
Microscopy, Fluorescence - methods
Microscopy, Fluorescence - trends
Protein Interaction Mapping - methods
Protein Interaction Mapping - trends
Q1
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Image-based screening (IBS) has proven itself with whole-well assays in which throughput and assay miniaturization are priorities. Recent interest, however, has centered upon the use of automated imaging technology to conduct assays at subcellular resolution. These in vitro assays have the potential to increase lead quality at early stages in drug discovery. Subcellular IBS is not yet mature and, although some assays provide reliable data at reasonable throughput, many others have yet to demonstrate robust application. Developments in image acquisition, analysis and informatics technologies are ongoing and are expected to broaden the usefulness of subcellular IBS.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2004.12.005