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Pharmacokinetics of clorazepate in pregnant and non-pregnant women
A single dose of clorazepate 20 mg was injected i.m. in 7 pregnant and 7 non-pregnant women. Blood samples were collected for one week, and urine was collected for 24 h after the dose. The concentrations of clorazepate and its metabolite nordiazepam were determined by electron capture gas liquid chr...
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Published in: | European journal of clinical pharmacology 1979-05, Vol.15 (3), p.175-180 |
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container_title | European journal of clinical pharmacology |
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creator | Rey, E d'Athis, P Giraux, P de Lauture, D Turquais, J M Chavinie, J Olive, G |
description | A single dose of clorazepate 20 mg was injected i.m. in 7 pregnant and 7 non-pregnant women. Blood samples were collected for one week, and urine was collected for 24 h after the dose. The concentrations of clorazepate and its metabolite nordiazepam were determined by electron capture gas liquid chromatography. There was no difference between the two groups on physical examinations. Clorazepate was rapidly absorbed and the peak concentration was reached within 2 h. Mean pharmacokinetic parameters for clorazepate were absorption half life 0.77 h in pregnant women and 0.56 h in non-pregnant women; elimination half life 1.3 h in pregnant women and 2.0 h in non-pregnant women; volume of distribution: 0.43 1 . kg-1 in the pregnant women and 0.33 1 . kg-1 in non-pregnant women. Nordiazepam reached its peak concentration within 12 h after dosing; its mean half life of elimination was 180 h in pregnant women and 60 h in non-pregnant women. Within 24 h, 1.3% of the clorazepate was recovered in urine from pregnant women and 7% in urine from the non-pregnant women. |
doi_str_mv | 10.1007/bf00563102 |
format | article |
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Blood samples were collected for one week, and urine was collected for 24 h after the dose. The concentrations of clorazepate and its metabolite nordiazepam were determined by electron capture gas liquid chromatography. There was no difference between the two groups on physical examinations. Clorazepate was rapidly absorbed and the peak concentration was reached within 2 h. Mean pharmacokinetic parameters for clorazepate were absorption half life 0.77 h in pregnant women and 0.56 h in non-pregnant women; elimination half life 1.3 h in pregnant women and 2.0 h in non-pregnant women; volume of distribution: 0.43 1 . kg-1 in the pregnant women and 0.33 1 . kg-1 in non-pregnant women. Nordiazepam reached its peak concentration within 12 h after dosing; its mean half life of elimination was 180 h in pregnant women and 60 h in non-pregnant women. 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Blood samples were collected for one week, and urine was collected for 24 h after the dose. The concentrations of clorazepate and its metabolite nordiazepam were determined by electron capture gas liquid chromatography. There was no difference between the two groups on physical examinations. Clorazepate was rapidly absorbed and the peak concentration was reached within 2 h. Mean pharmacokinetic parameters for clorazepate were absorption half life 0.77 h in pregnant women and 0.56 h in non-pregnant women; elimination half life 1.3 h in pregnant women and 2.0 h in non-pregnant women; volume of distribution: 0.43 1 . kg-1 in the pregnant women and 0.33 1 . kg-1 in non-pregnant women. Nordiazepam reached its peak concentration within 12 h after dosing; its mean half life of elimination was 180 h in pregnant women and 60 h in non-pregnant women. Within 24 h, 1.3% of the clorazepate was recovered in urine from pregnant women and 7% in urine from the non-pregnant women.</description><subject>Adult</subject><subject>Anti-Anxiety Agents - metabolism</subject><subject>Biotransformation</subject><subject>Body Fluids - metabolism</subject><subject>Clorazepate Dipotassium - metabolism</subject><subject>Female</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Pregnancy</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><recordid>eNo9kDFPwzAUhC1EBaWwsLJkYkAKvBc7dj3SigJSJRhgjl4cBwKJHexUCH49hZZOJ50-nXQfY6cIlwigrsoaIJccIdtjYxQ8SxEE7rMxAMdUagWH7CjGNwDMNfADNuIKpnrMZo-vFDoy_r1xdmhMTHydmNYH-rY9DTZpXNIH--LIDQm5KnHepbvi03fWHbNRTW20J9ucsOfFzdP8Ll0-3N7Pr5ep4UIOqUJhVKVJVUJITZoEIQmUJGSFU0VlLmqsiec6N0qrstKgKc_XZ5CQg-ATdr7Z7YP_WNk4FF0TjW1bctavYqGEzCBTv-DFBjTBxxhsXfSh6Sh8FQjFr65itvjXtYbPtqursrPVDv3zw38AtJRjjQ</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>Rey, E</creator><creator>d'Athis, P</creator><creator>Giraux, P</creator><creator>de Lauture, D</creator><creator>Turquais, J M</creator><creator>Chavinie, J</creator><creator>Olive, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197905</creationdate><title>Pharmacokinetics of clorazepate in pregnant and non-pregnant women</title><author>Rey, E ; d'Athis, P ; Giraux, P ; de Lauture, D ; Turquais, J M ; Chavinie, J ; Olive, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-714c7d9a7d4469a9a4a1a416a46d187ab54f1fa3595c797bd909a551431a13043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Anti-Anxiety Agents - metabolism</topic><topic>Biotransformation</topic><topic>Body Fluids - metabolism</topic><topic>Clorazepate Dipotassium - metabolism</topic><topic>Female</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rey, E</creatorcontrib><creatorcontrib>d'Athis, P</creatorcontrib><creatorcontrib>Giraux, P</creatorcontrib><creatorcontrib>de Lauture, D</creatorcontrib><creatorcontrib>Turquais, J M</creatorcontrib><creatorcontrib>Chavinie, J</creatorcontrib><creatorcontrib>Olive, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rey, E</au><au>d'Athis, P</au><au>Giraux, P</au><au>de Lauture, D</au><au>Turquais, J M</au><au>Chavinie, J</au><au>Olive, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of clorazepate in pregnant and non-pregnant women</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1979-05</date><risdate>1979</risdate><volume>15</volume><issue>3</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>A single dose of clorazepate 20 mg was injected i.m. in 7 pregnant and 7 non-pregnant women. Blood samples were collected for one week, and urine was collected for 24 h after the dose. The concentrations of clorazepate and its metabolite nordiazepam were determined by electron capture gas liquid chromatography. There was no difference between the two groups on physical examinations. Clorazepate was rapidly absorbed and the peak concentration was reached within 2 h. Mean pharmacokinetic parameters for clorazepate were absorption half life 0.77 h in pregnant women and 0.56 h in non-pregnant women; elimination half life 1.3 h in pregnant women and 2.0 h in non-pregnant women; volume of distribution: 0.43 1 . kg-1 in the pregnant women and 0.33 1 . kg-1 in non-pregnant women. Nordiazepam reached its peak concentration within 12 h after dosing; its mean half life of elimination was 180 h in pregnant women and 60 h in non-pregnant women. Within 24 h, 1.3% of the clorazepate was recovered in urine from pregnant women and 7% in urine from the non-pregnant women.</abstract><cop>Germany</cop><pmid>37089</pmid><doi>10.1007/bf00563102</doi><tpages>6</tpages></addata></record> |
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source | Springer Nature - Connect here FIRST to enable access |
subjects | Adult Anti-Anxiety Agents - metabolism Biotransformation Body Fluids - metabolism Clorazepate Dipotassium - metabolism Female Half-Life Humans Kinetics Pregnancy |
title | Pharmacokinetics of clorazepate in pregnant and non-pregnant women |
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