Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosis

• Published in: Pediatric allergy and immunology 2010-05, Vol.21 (3), p.493-500
• Main Authors: Robroeks, Charlotte M. H. H. T., Roozeboom, Marieke H., De Jong, Pim A., Tiddens, Harm A. W. M., Jöbsis, Quirijn, Hendriks, Han J., Yntema, Jan-Bart L., Brackel, Hein L., Van Gent, Rene, Robben, Simon, Dompeling, Edward
• Format: Article
• Language: English
• Subjects: Adolescent; Biological and medical sciences; Biomarkers - analysis; Child; cystic fibrosis; Cystic Fibrosis - diagnostic imaging; Cystic Fibrosis - physiopathology; Errors of metabolism; Exhalation; exhaled breath condensate; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; high resolution computed tomography; Humans; Inflammation - metabolism; Lung - diagnostic imaging; Lung - physiology; Lung - physiopathology; lung changes; lung function; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; non-invasive inflammatory markers; Pseudomonas; Respiratory Function Tests; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Severity of Illness Index; Tomography, X-Ray Computed - methods
• ISSN: 0905-6157; 1399-3038
• DOI: 10.1111/j.1399-3038.2009.00872.x

Robroeks CMHHT, Roozeboom MH, de Jong PA, Tiddens HAWM, Jöbsis Q, Hendriks HJ, Yntema J‐BL, Brackel HL, van Gent R, Robben S, Dompeling E. Structural lung changes, lung function, and non‐invasive inflammatory markers in cystic fibrosis.
Pediatr Allergy Immunol 2010: 21: 493–500.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard Cystic fibrosis (CF) lung disease is characterized by chronic airway inflammation and recurrent infections, resulting in (ir)reversible structural lung changes and a progressive decline in lung function. The objective of this study was to investigate the relationship between non‐invasive inflammatory markers (IM) in exhaled breath condensate (EBC), lung function indices and structural lung changes, visualized by high resolution computed tomography (HRCT) scans in CF. In 34 CF patients, lung function indices (forced expiratory volume in 1 s, forced vital capacity [FVC], residual volume, and total lung capacity [TLC]) and non‐invasive IM (exhaled nitric oxide, and condensate acidity, nitrate, nitrite, 8‐isoprostane, hydrogen peroxide, interferon‐gamma) were assessed. HRCT scans were scored in a standardized and validated way, a composite score and component scores were calculated. In general, the correlations between non‐invasive IM and structural lung changes, and between IM and lung function were low (correlation coefficients