Tamoxifen combined to anti-HER-2/neu cell vaccine does not hamper cancer immunopreventive efficacy

Abstract The possible interference of tamoxifen with anti-tumor vaccines was studied in a translational view of combined preventive approaches. Tamoxifen treatment of HER-2/neu transgenic mice combined to anti-HER-2/neu cell vaccine did not hamper the efficacy of cancer immunoprevention, and caused...

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Bibliographic Details
Published in:Vaccine 2009-03, Vol.27 (14), p.2065-2069
Main Authors: De Giovanni, Carla, Nicoletti, Giordano, Landuzzi, Lorena, Croci, Stefania, Palladini, Arianna, Antognoli, Agnese, Murgo, Annalisa, Ianzano, Marianna L, Grosso, Valentina, Stivani, Valeria, Iezzi, Manuela, Musiani, Piero, Nanni, Patrizia, Lollini, Pier-Luigi
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
Animals
Antineoplastic Agents, Hormonal - therapeutic use
Applied microbiology
Biological and medical sciences
Breast cancer
Cancer Vaccines - immunology
Cancer Vaccines - therapeutic use
Carcinoma - immunology
Carcinoma - prevention & control
Cells, Cultured
Colleges & universities
Combined Modality Therapy
Cytokines
Female
Fundamental and applied biological sciences. Psychology
Genes, erbB-2 - genetics
Genes, erbB-2 - immunology
Interferon-gamma - biosynthesis
Kinases
Mammary Neoplasms, Experimental - immunology
Mammary Neoplasms, Experimental - prevention & control
Medical research
Medical sciences
Mice
Mice, Transgenic
Microbiology
Mortality
Rodents
Scholarships & fellowships
Spleen - immunology
Spleen - metabolism
Tamoxifen
Tamoxifen - therapeutic use
Transgenic animals
Tumors
Vaccination
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Description
Summary:Abstract The possible interference of tamoxifen with anti-tumor vaccines was studied in a translational view of combined preventive approaches. Tamoxifen treatment of HER-2/neu transgenic mice combined to anti-HER-2/neu cell vaccine did not hamper the efficacy of cancer immunoprevention, and caused a significantly increased production of interferon-γ. These data suggest that tamoxifen could even have a positive impact on the efficacy of cancer immunoprevention.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.01.113