SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

• Published in: European journal of clinical nutrition 2010-01, Vol.64 (1), p.105-107
• Main Authors: Hwang, J-Y, Park, J.E, Choi, Y.J, Huh, K.B, Kim, W.Y
• Format: Article
• Language: English
• Subjects: adiponectin; Adiponectin - blood; Adiponectin - genetics; Aged; Analysis; Biological and medical sciences; Clinical Nutrition; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Genes; Genetic aspects; Genetic Association Studies; genetic polymorphism; Genetic Predisposition to Disease; Genotype; Health aspects; human diseases; Humans; Internal Medicine; Korea; Logistic Models; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - genetics; Metabolic syndrome X; Middle Aged; Miscellaneous; noninsulin-dependent diabetes mellitus; Other metabolic disorders; patients; Polymorphism, Single Nucleotide; Protein hormones; Public Health; Regression analysis; Risk Factors; short-communication; Single nucleotide polymorphisms; Type 2 diabetes; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2009.94

Few studies have examined an association between SNP276 and the risk of metabolic syndrome (MetS), which accelerates the development of diabetic complications, in patients with type II diabetes mellitus (T2DM). This study examined whether the SNP276G>T polymorphism is associated with risk of MetS in 673 Korean patients with T2DM from an ongoing prospective study. Multiple logistic regression analysis revealed that the OR for MetS was greater in patients with the TT genotype than in those with the GG genotype (OR=2.071; 95% CI=1.088–3.943) after adjustment of the putative risk factors for MetS. After examining the relationship between serum adiponectin and MetS risk for each genotype, only in patients with the GT genotype, serum adiponectin was negatively associated with the risk of MetS (OR=0.287; 95% CI=0.193–0.427). The SNP276G>T polymorphism may have an independent role in the determination of MetS in Korean patients with T2DM.