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MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon
IT has long been recognized that the absence of expression of products of the major histocompatibility complex (MHC) during early development might allow the fetus to escape recognition by maternal lymphocytes. In addition to the MHC class I heavy chain and β 2 -microglobulin, antigenic peptide is a...
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| Published in: | Nature (London) 1991-11, Vol.354 (6350), p.235-238 |
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| Main Authors: | , , , , , |
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| container_end_page | 238 |
| container_issue | 6350 |
| container_start_page | 235 |
| container_title | Nature (London) |
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| creator | Bikoff, Elizabeth K Jaffe, Leah Ribaudo, Randall K Otten, Gillis R Germain, Ronald N Robertson, Elizabeth J |
| description | IT has long been recognized that the absence of expression of products of the major histocompatibility complex (MHC) during early development might allow the fetus to escape recognition by maternal lymphocytes. In addition to the MHC class I heavy chain and
β
2
-microglobulin, antigenic peptide is an essential structural component of the class I molecule
1–5
. Indeed, there is evidence that MHC-linked genes encoding peptide transporter molecules
6–10
and possibly components of a proteolytic complex
11,12
are necessary for MHC class I assembly and stability at the cell surface. Here we demonstrate that embryonic cells in general show a defect in MHC class I assembly. Surface expression was rescued in the presence of an appropriate antigenic peptide, or by treatment with interferon. Consistent with this, HAM1 (ref. 9) messenger RNA was not constitutively expressed, but was inducible by interferon, and during differentiation
in vitro
. Thus, tolerance of the fetal allograft may in part be controlled at the level of peptide-dependent MHC class I assembly. |
| doi_str_mv | 10.1038/354235a0 |
| format | article |
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β
2
-microglobulin, antigenic peptide is an essential structural component of the class I molecule
1–5
. Indeed, there is evidence that MHC-linked genes encoding peptide transporter molecules
6–10
and possibly components of a proteolytic complex
11,12
are necessary for MHC class I assembly and stability at the cell surface. Here we demonstrate that embryonic cells in general show a defect in MHC class I assembly. Surface expression was rescued in the presence of an appropriate antigenic peptide, or by treatment with interferon. Consistent with this, HAM1 (ref. 9) messenger RNA was not constitutively expressed, but was inducible by interferon, and during differentiation
in vitro
. Thus, tolerance of the fetal allograft may in part be controlled at the level of peptide-dependent MHC class I assembly.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/354235a0</identifier><identifier>PMID: 1720508</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>AIDS/HIV ; Animals ; Antigens ; beta 2-Microglobulin - pharmacology ; Biological and medical sciences ; Blotting, Northern ; Cell Line ; Cell Membrane - immunology ; Cell Membrane - metabolism ; Cellular biology ; Electrophoresis, Polyacrylamide Gel ; Embryo, Mammalian - immunology ; Embryo, Mammalian - metabolism ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; gag Gene Products, Human Immunodeficiency Virus ; Gene Expression Regulation - drug effects ; Gene Products, gag - pharmacology ; Genetics ; H-2 Antigens - biosynthesis ; Histocompatibility antigens (hla, h-2 and other systems) ; Humanities and Social Sciences ; Interferons - pharmacology ; letter ; Lymphocytes ; Mice ; Molecular immunology ; multidisciplinary ; Peptides - pharmacology ; Prenatal development ; RNA - biosynthesis ; Science ; Science (multidisciplinary) ; Transfection</subject><ispartof>Nature (London), 1991-11, Vol.354 (6350), p.235-238</ispartof><rights>Springer Nature Limited 1991</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 21, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-4fc710c99a65690c48accfc1b7b1079535d427c37826a905080dae36423871a93</citedby><cites>FETCH-LOGICAL-c486t-4fc710c99a65690c48accfc1b7b1079535d427c37826a905080dae36423871a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2725,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5174443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1720508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bikoff, Elizabeth K</creatorcontrib><creatorcontrib>Jaffe, Leah</creatorcontrib><creatorcontrib>Ribaudo, Randall K</creatorcontrib><creatorcontrib>Otten, Gillis R</creatorcontrib><creatorcontrib>Germain, Ronald N</creatorcontrib><creatorcontrib>Robertson, Elizabeth J</creatorcontrib><title>MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IT has long been recognized that the absence of expression of products of the major histocompatibility complex (MHC) during early development might allow the fetus to escape recognition by maternal lymphocytes. In addition to the MHC class I heavy chain and
β
2
-microglobulin, antigenic peptide is an essential structural component of the class I molecule
1–5
. Indeed, there is evidence that MHC-linked genes encoding peptide transporter molecules
6–10
and possibly components of a proteolytic complex
11,12
are necessary for MHC class I assembly and stability at the cell surface. Here we demonstrate that embryonic cells in general show a defect in MHC class I assembly. Surface expression was rescued in the presence of an appropriate antigenic peptide, or by treatment with interferon. Consistent with this, HAM1 (ref. 9) messenger RNA was not constitutively expressed, but was inducible by interferon, and during differentiation
in vitro
. Thus, tolerance of the fetal allograft may in part be controlled at the level of peptide-dependent MHC class I assembly.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antigens</subject><subject>beta 2-Microglobulin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell Line</subject><subject>Cell Membrane - immunology</subject><subject>Cell Membrane - metabolism</subject><subject>Cellular biology</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Embryo, Mammalian - immunology</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>gag Gene Products, Human Immunodeficiency Virus</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Products, gag - pharmacology</subject><subject>Genetics</subject><subject>H-2 Antigens - biosynthesis</subject><subject>Histocompatibility antigens (hla, h-2 and other systems)</subject><subject>Humanities and Social Sciences</subject><subject>Interferons - pharmacology</subject><subject>letter</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Molecular immunology</subject><subject>multidisciplinary</subject><subject>Peptides - pharmacology</subject><subject>Prenatal development</subject><subject>RNA - biosynthesis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Transfection</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqN0k1v1DAQBmALgcp2QeIPgCxU8XEIjL-dI1pRWqmIC5yD40zAVTYJdgLtv8erLFupQoWTJb-PxmOPCXnC4A0DYd8KJblQDu6RFZNGF1Jbc5-sALgtwAr9kByndAkAihl5RI6Y4aDArsjXj2cb6juXEj2naY6t80jxaoyYUhh6GnqK2zpeD0WDMfzEhnrsOtqFHlMOm9mHukP6K0zf6YjjFBqkQ8zJhLHFOPSPyIPWdQkf79c1-XL6_vPmrLj49OF88-6i8NLqqZCtNwx8WTqtdAl503nfelabmoEplVCN5MYLY7l25a53aBwKna9tDXOlWJOXS90xDj9mTFO1DWnXq-txmFNlpOaCgVT_IYUApqzJ8sXdksvS8FL9EzLNQOdhZPj8Frwc5tjnh6k4SMkV0zKjVwvycUgpYluNMWxdvK4YVLtxV3_GnenTfb253mJzA5f55vxkn7vkXddG1_uQDmz3G2S-7pq8XljKSf8N401bfzny2WJ7N80RD7UO4DcRc8WR</recordid><startdate>19911121</startdate><enddate>19911121</enddate><creator>Bikoff, Elizabeth K</creator><creator>Jaffe, Leah</creator><creator>Ribaudo, Randall K</creator><creator>Otten, Gillis R</creator><creator>Germain, Ronald N</creator><creator>Robertson, Elizabeth J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>19911121</creationdate><title>MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon</title><author>Bikoff, Elizabeth K ; 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In addition to the MHC class I heavy chain and
β
2
-microglobulin, antigenic peptide is an essential structural component of the class I molecule
1–5
. Indeed, there is evidence that MHC-linked genes encoding peptide transporter molecules
6–10
and possibly components of a proteolytic complex
11,12
are necessary for MHC class I assembly and stability at the cell surface. Here we demonstrate that embryonic cells in general show a defect in MHC class I assembly. Surface expression was rescued in the presence of an appropriate antigenic peptide, or by treatment with interferon. Consistent with this, HAM1 (ref. 9) messenger RNA was not constitutively expressed, but was inducible by interferon, and during differentiation
in vitro
. Thus, tolerance of the fetal allograft may in part be controlled at the level of peptide-dependent MHC class I assembly.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1720508</pmid><doi>10.1038/354235a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1991-11, Vol.354 (6350), p.235-238 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_746231045 |
| source | Nature Journals |
| subjects | AIDS/HIV Animals Antigens beta 2-Microglobulin - pharmacology Biological and medical sciences Blotting, Northern Cell Line Cell Membrane - immunology Cell Membrane - metabolism Cellular biology Electrophoresis, Polyacrylamide Gel Embryo, Mammalian - immunology Embryo, Mammalian - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology gag Gene Products, Human Immunodeficiency Virus Gene Expression Regulation - drug effects Gene Products, gag - pharmacology Genetics H-2 Antigens - biosynthesis Histocompatibility antigens (hla, h-2 and other systems) Humanities and Social Sciences Interferons - pharmacology letter Lymphocytes Mice Molecular immunology multidisciplinary Peptides - pharmacology Prenatal development RNA - biosynthesis Science Science (multidisciplinary) Transfection |
| title | MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon |
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