Aberrant Expression of CD8 in B-Cell Non-Hodgkin Lymphoma: A Multicenter Study of 951 Bone Marrow Samples With Lymphomatous Infiltration

T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in whic...

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Bibliographic Details
Published in:American journal of clinical pathology 2009-08, Vol.132 (2), p.186-190
Main Authors: CARULLI, Giovanni, STACCHINI, Alessandra, CALLEGARI, Tiziana, PETRINI, Mario, MARINI, Alessandra, MATILDE CIRIELLO, Maria, ZUCCA, Alessandra, CANNIZZO, Elisa, ALIBERTI, Sabrina, DEMURTAS, Anna, NOVERO, Domenico, CALCAGNO, Lara
Format: Article
Language:English
Subjects:
Antigens, CD19 - biosynthesis
Biological and medical sciences
Biomarkers, Tumor - analysis
Bone Marrow - metabolism
Bone Marrow - pathology
CD5 Antigens - biosynthesis
CD8 Antigens - biosynthesis
Flow Cytometry
Hematologic and hematopoietic diseases
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell - metabolism
Lymphoma, B-Cell - pathology
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Retrospective Studies
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Summary:T-cell antigen expression can be observed in B-cell non-Hodgkin lymphoma (B-NHL). Although CD5 is expressed in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma, the presence of other T-cell antigens is less common. This article reports a retrospective multicenter analysis in which flow cytometry was used to evaluate aberrant CD8 expression on the pathologic B cells of 951 bone marrow samples from patients with various types of B-NHL. In a total of 18 patients, CD8 was coexpressed: 10 had B-CLL; 1, small lymphocytic lymphoma (SLL); 1, marginal zone lymphoma; 1, lymphoplasmacytic lymphoma; 2, diffuse large B-cell lymphoma; and 3, follicular lymphoma. There was a 1.89% overall frequency of CD8 coexpression in which B-CLL/SLL had a higher frequency (3.03%) than did the other B-cell neoplasms (1.18%). Most cases were characterized by a favorable outcome.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPNCOHS92ARWRQ