Topographical Functional Connectivity Pattern in the Perisylvian Language Networks

We performed a resting-state functional connectivity study to investigate directly the functional correlations within the perisylvian language networks by seeding from 3 subregions of Broca's complex (pars opercularis, pars triangularis, and pars orbitalis) and their right hemisphere homologues...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2010-03, Vol.20 (3), p.549-560
Main Authors: Xiang, Hua-Dong, Fonteijn, Hubert M., Norris, David G., Hagoort, Peter
Format: Article
Language:English
Subjects:
Adult
Brain Mapping
Broca's complex
Female
Frontal Lobe - blood supply
Frontal Lobe - physiology
Functional Laterality - physiology
functional organization
Humans
Image Processing, Computer-Assisted - methods
Language
Language Tests
Magnetic Resonance Imaging - methods
Male
Nerve Net - blood supply
Nerve Net - physiology
Neural Pathways - blood supply
Neural Pathways - physiology
Oxygen - blood
pars opercularis (BA 44)
pars orbitalis (BA 47)
pars triangularis (BA 45)
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Summary:We performed a resting-state functional connectivity study to investigate directly the functional correlations within the perisylvian language networks by seeding from 3 subregions of Broca's complex (pars opercularis, pars triangularis, and pars orbitalis) and their right hemisphere homologues. A clear topographical functional connectivity pattern in the left middle frontal, parietal, and temporal areas was revealed for the 3 left seeds. This is the first demonstration that a functional connectivity topology can be observed in the perisylvian language networks. The results support the assumption of the functional division for phonology, syntax, and semantics of Broca's complex as proposed by the memory, unification, and control (MUC) model and indicated a topographical functional organization in the perisylvian language networks, which suggests a possible division of labor for phonological, syntactic, and semantic function in the left frontal, parietal, and temporal areas.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhp119