Metabolic differences between male and female adolescents with non-alcoholic fatty liver disease, as detected by ultrasound

Background:  Age, developmental stage and gender are risk factors for paediatric non‐alcoholic fatty liver disease (NAFLD). Aims:  The aim of this study was to identify differences in clinical or laboratory variables between sexes in adolescents with NAFLD. Methodology:  Ninety obese adolescents inc...

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Bibliographic Details
Published in:Acta Paediatrica 2010-08, Vol.99 (8), p.1218-1223
Main Authors: Fernandes, MTB, Ferraro, AA, De Azevedo, RA, Fagundes Neto, U
Format: Article
Language:English
Subjects:
Adolescent
Anthropometry
Biological and medical sciences
Body Composition
Brazil - epidemiology
Child
Cholesterol - blood
Developmental stage
Fatty Liver - diagnostic imaging
Fatty Liver - epidemiology
Fatty Liver - metabolism
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gender
General aspects
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Non-alcoholic fatty liver disease
Obesity - complications
Obesity - metabolism
Other diseases. Semiology
Paediatrics
Predictive Value of Tests
Prevalence
Risk Factors
Sex Factors
Ultrasonography
Young Adult
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Summary:Background:  Age, developmental stage and gender are risk factors for paediatric non‐alcoholic fatty liver disease (NAFLD). Aims:  The aim of this study was to identify differences in clinical or laboratory variables between sexes in adolescents with NAFLD. Methodology:  Ninety obese adolescents including 36 males and 54 females were evaluated. Inclusion criteria for this study were a Body Mass Index above the 95th percentile, as set forth by the National Center for Health Statistics, and an age of 10–19 years. A clinical and laboratory evaluation was conducted for all adolescents. Results:  The variables that were found to be predictive of NAFLD in adolescence were visceral fat, Aminotransferase, Gamma‐Glutamyl Transferase, triglyderides, cholesterol and LDL‐cholesterol. We also observed that cholesterol and LDL‐cholesterol variables were influenced by gender, i.e. there was a significant statistical difference in the values of these variables between male and female adolescents. With regard to cholesterol serum concentrations, the risk was 6.99 times greater for females, compared with 1.2 times for males; and for LDL‐cholesterol serum concentrations the risk was 8.15 times greater for females, compared with and 1.26 times for males. Conclusion:  Female adolescents with NAFLD showed a significantly different metabolic behaviour than males.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2010.01774.x