Neurological, imaging and pathological features of a meningeal inflammatory pseudotumour in a Maltese terrier

• Published in: Journal of small animal practice 2010-07, Vol.51 (7), p.387-392
• Main Authors: Loderstedt, S, Walmsley, G.L, Summers, B.A, Cappello, R, Volk, H.A
• Format: Article
• Language: English
• Subjects: Animals; ataxia (disorder); case studies; debulking; disease diagnosis; dog diseases; Dog Diseases - diagnosis; Dog Diseases - pathology; Dog Diseases - surgery; Dogs; Granuloma, Plasma Cell - diagnosis; Granuloma, Plasma Cell - pathology; Granuloma, Plasma Cell - surgery; Granuloma, Plasma Cell - veterinary; histopathology; Immunomodulation; inflammatory pseudotumour; Laminectomy - veterinary; magnetic resonance imaging; Magnetic Resonance Imaging - veterinary; Male; Maltese Terrier (dog breed); myelogram; neoplasms; Neurologic Examination - veterinary; paraparesis; prednisolone; spinal cord; Spinal Cord Diseases - diagnosis; Spinal Cord Diseases - pathology; Spinal Cord Diseases - surgery; Spinal Cord Diseases - veterinary; terriers; Treatment Outcome
• ISSN: 0022-4510; 1748-5827
• DOI: 10.1111/j.1748-5827.2010.00931.x

A five-year eight-month-old Maltese terrier was presented with a 3-week history of progressive paraparesis and pelvic limb ataxia. Neurological examination was consistent with a lesion involving the T3-L3 spinal cord segments. Myelogram and magnetic resonance imaging revealed a spherical, intradural-extramedullary mass lesion at T13/L1. A dorsal laminectomy, durotomy and debulking of the mass were performed. Histopathologic examination revealed a highly cellular tissue, most likely of mesenchymal origin, infiltrated by many lymphocytes, macrophages and neutrophils. The pathological diagnosis of an inflammatory pseudotumour was made. Postsurgical analgesia was achieved with opioids and 2 mg/kg carprofen twice daily for 5 days. When the histopathological diagnosis was made, a tapering course of 1 mg/kg prednisolone twice daily was prescribed, with dose reduction by approximately 50% every 4 to 6 weeks over a 4-month period. Magnetic resonance imaging was repeated at 22, 32 and 85 weeks postsurgery; no signs of regrowth could be detected and the patient recovered with residual mild paraparesis. Inflammatory pseudotumour has not been documented previously at this site in dogs and, although rare, should be considered in the differential diagnosis of a focal mass lesion affecting the spinal cord. Surgical debulking and immunomodulatory therapy can be curative.