The risk of psoriatic arthritis remains constant following initial diagnosis of psoriasis among patients seen in European dermatology clinics

Background  Estimates of psoriatic arthritis (PsA) prevalence among psoriasis patients vary widely (5–40%). The time to development of PsA in patients with plaque psoriasis also remains unclear. Objectives  To examine whether length of time since diagnosis of psoriasis affects risk of developing PsA...

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Published in:Journal of the European Academy of Dermatology and Venereology 2010-05, Vol.24 (5), p.548-554
Main Authors: Christophers, E, Barker, JNWN, Griffiths, CEM, Daudén, E, Milligan, G, Molta, C, Sato, R, Boggs, R
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic - complications
Arthritis, Psoriatic - epidemiology
comorbidities
Cross-Sectional Studies
Europe
healthcare resource utilization
Humans
incidence
prevalence
psoriasis
psoriatic arthritis
Quality of Life
work productivity
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Summary:Background  Estimates of psoriatic arthritis (PsA) prevalence among psoriasis patients vary widely (5–40%). The time to development of PsA in patients with plaque psoriasis also remains unclear. Objectives  To examine whether length of time since diagnosis of psoriasis affects risk of developing PsA, and to assess differences in quality of life (QoL), work‐related issues, comorbidities and healthcare resource utilization (HCRU) for patients with PsA vs. psoriasis. Methods  This large cross‐sectional observational study was conducted in the UK, Italy, France, Spain and Germany in 2006. Dermatologists who actively treated patients with psoriasis recruited 10 consecutive patients with psoriasis. Presence of PsA, body surface area (BSA) affected with psoriasis and HCRU were recorded; patients completed EUROQoL (EQ5D) and employment disadvantages questionnaires. Results  Patients with psoriasis (n = 1560) included 126 with PsA. Ninety per cent of these patients with PsA were seen by dermatologists who involved a rheumatologist in the care of their patients with PsA. Survival analysis indicated that the incidence of PsA among psoriasis patients remained constant (74 per 1000 person‐years), while the prevalence increased with time since diagnosis of psoriasis, reaching 20.5% after 30 years. In addition, those with high BSA currently affected by psoriasis were more likely to have developed PsA (P 
ISSN:0926-9959
1468-3083
DOI:10.1111/j.1468-3083.2009.03463.x