Inflammatory Response and Apoptosis in Newborn Lungs after Meconium Aspiration

An important feature of meconium‐instilled newborn lungs is an inflammatory response and apoptotic cell death. It was recently demonstrated by our group and supported by several other investigators in a relatively short period of time. Apoptosis exists also in healthy lungs, but in meconium‐instille...

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Bibliographic Details
Published in:Biotechnology progress 2005, Vol.21 (1), p.192-197
Main Authors: Vidyasagar, D., Lukkarinen, H., Kaapa, P., Zagariya, A.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - immunology
Apoptosis
Apoptosis - immunology
Biological and medical sciences
Biotechnology
Cell size
Cytology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Humans
Infant, Newborn
Inflammation
Inflammation - immunology
Lung
Lung - immunology
Meconium
Meconium Aspiration Syndrome - immunology
Meconium Aspiration Syndrome - physiopathology
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Summary:An important feature of meconium‐instilled newborn lungs is an inflammatory response and apoptotic cell death. It was recently demonstrated by our group and supported by several other investigators in a relatively short period of time. Apoptosis exists also in healthy lungs, but in meconium‐instilled lungs its level is usually dramatically higher. Apoptosis is characterized by loss of cell function, decrease in cell size, and its morphology. Apoptosis plays an important role in normal cell life, but increased levels of apoptosis induce great damage for any tissues. Apoptosis in the lungs has been greatly overlooked for the past decade, and meconium‐induced apoptosis is a relatively new event and not effectively studied at the present time. This Review summarized current knowledge regarding meconium‐induced inflammation and apoptosis in newborn lungs.
ISSN:8756-7938
1520-6033
DOI:10.1021/bp0497886