Anterior Cruciate Ligament Reconstruction Using Chitin-coated Fabrics in a Rabbit Model

Experimental anterior cruciate ligament (ACL) reconstruction was carried out in a rabbit model, in which a chitin‐coated polyester graft was used as the scaffold, and a noncoated graft was used as a control graft. After 8 weeks implantation, a mechanical test of the knee and histometric measurement...

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Bibliographic Details
Published in:Artificial organs 2010-01, Vol.34 (1), p.55-64
Main Authors: Kawai, Tomoyuki, Yamada, Takeki, Yasukawa, Akio, Koyama, Yoshihisa, Muneta, Takeshi, Takakuda, Kazuo
Format: Article
Language:English
Subjects:
Animals
Anterior Cruciate Ligament - pathology
Anterior Cruciate Ligament - surgery
Biomaterials
Bioprosthesis
Chitin
Chitin - therapeutic use
Chitosan
Joint Prosthesis
Ligament
Male
Materials Testing
Nonwoven fabric
Polyesters - therapeutic use
Prosthesis Implantation
Rabbits
Recovery of Function
Regeneration
Tensile Strength
Tissue Scaffolds
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Summary:Experimental anterior cruciate ligament (ACL) reconstruction was carried out in a rabbit model, in which a chitin‐coated polyester graft was used as the scaffold, and a noncoated graft was used as a control graft. After 8 weeks implantation, a mechanical test of the knee and histometric measurement of the graft and surrounding tissues were carried out. A tensile test of the femur‐graft‐tibia specimen showed that the knee treated with the coated graft had a peak resistance force of 42.2 ± 12.7 N, which was significantly greater than the 19.2 ± 15.3 N of the knee treated with the control graft. The histometric measurement revealed that the area of bone tissue within the section of the coated graft in the femoral bone tunnel was 3.43 ±  1.73 mm2, which was significantly greater than the area of 0.29 ± 0.37 mm2 of the control graft. Similarly, the area of soft tissue within and around the midsubstance of the coated graft located in the articular cavity was significantly greater than that of the control graft. The chitin coating enhanced the formation of bone tissue in the femoral bone tunnel and soft tissue in the articular cavity, and increased the attachment strength of the graft to the bone. Thus, the efficacy of the chitin coating for the ACL reconstruction scaffolds was demonstrated.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2009.00786.x