Interleukin-6 as an early predictor for one-year survival following an ischaemic stroke/transient ischaemic attack

Background Early biomarkers for survival in an acute ischaemic stroke/transient ischaemic attack might serve as a useful tool for the clinician. Several studies have highlighted the role of inflammatory biomarkers as an early signal for acute ischaemic stroke prognosis. Aims This study examines the...

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Bibliographic Details
Published in:International journal of stroke 2010-02, Vol.5 (1), p.16-20
Main Authors: Shenhar-Tsarfaty, S., Assayag, E. Ben, Bova, I., Shopin, L., Fried, M., Berliner, S., Shapira, I., Bornstein, N. M.
Format: Article
Language:English
Subjects:
acute
Acute Disease
Aged
Algorithms
Brain Ischemia - blood
Brain Ischemia - complications
Brain Ischemia - mortality
Enzyme-Linked Immunosorbent Assay
Female
Humans
inflammation
interleukin-6
Interleukin-6 - blood
Intracranial Thrombosis - mortality
ischaemic stroke
Ischemic Attack, Transient - blood
Ischemic Attack, Transient - mortality
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Models, Statistical
Odds Ratio
Predictive Value of Tests
Risk Factors
Signal Detection, Psychological
stroke
Stroke - blood
Stroke - etiology
Stroke - mortality
survival
Survival Analysis
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Summary:Background Early biomarkers for survival in an acute ischaemic stroke/transient ischaemic attack might serve as a useful tool for the clinician. Several studies have highlighted the role of inflammatory biomarkers as an early signal for acute ischaemic stroke prognosis. Aims This study examines the potential advantage of using high-sensitivity interleukin-6 as a possible biomarker at the early stages of acute stroke for identifying patients at a high risk for 12-month mortality. Methods Inflammatory biomarkers and neurological scores were determined in 250 patients following mild to moderate acute ischaemic stroke within 24 h of hospital admission. Outcome data on mortality were collected after 12 months. The signal detection methodology was used to identify subgroups that were at a high risk for 12-month mortality. Results Twelve months following the event, 234 of the 250 stroke patients survived. Signal detection identified predictors that distinguished individuals likely to die from those with a better recovery prediction. Plasma interleukin-6 concentration emerged as the optimal predictor, with a cut point of 6·47pg/ml, χ2 (I, N = 250) = 20·5, P
ISSN:1747-4930
1747-4949
DOI:10.1111/j.1747-4949.2009.00396.x