Risk factors for incident mild cognitive impairment - results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)

• Published in: Acta psychiatrica Scandinavica 2010-04, Vol.121 (4), p.260-272
• Main Authors: Luck, T., Riedel-Heller, S. G., Luppa, M., Wiese, B., Wollny, A., Wagner, M., Bickel, H., Weyerer, S., Pentzek, M., Haller, F., Moesch, E., Werle, J., Eisele, M., Maier, W., Van Den Bussche, H., Kaduszkiewicz, H.
• Format: Article
• Language: English
• Subjects: Age; Age Factors; Aged; Aged, 80 and over; Alleles; apoE ε4 allele; Apolipoprotein E4 - genetics; Biological and medical sciences; Cognition; Cognition & reasoning; Cognition Disorders - epidemiology; Cognition Disorders - etiology; Cognition Disorders - genetics; Cognition Disorders - prevention & control; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Dementia - complications; Dementia - epidemiology; Family Practice; Female; Gender; Geriatric psychology; Geriatrics; Germany; Humans; Incidence; Longitudinal Studies; Male; Medical sciences; Memory Disorders - complications; Memory Disorders - epidemiology; mild cognitive impairment; Neurology; Older people; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk Factors; Sex Factors; Vascular Diseases - complications; Vascular Diseases - epidemiology
• ISSN: 0001-690X; 1600-0447
• DOI: 10.1111/j.1600-0447.2009.01481.x

Luck T, Riedel‐Heller SG, Luppa M, Wiese B, Wollny A, Wagner M, Bickel H, Weyerer S, Pentzek M, Haller F, Moesch E, Werle J, Eisele M, Maier W, van den Bussche H, Kaduszkiewicz H for the AgeCoDe Study Group. Risk factors for incident mild cognitive impairment – results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Objectives:  To provide age‐ and gender‐specific incidence rates of MCI among elderly general practitioner (GP) patients (75+ years) and to identify risk factors for incident MCI. Method:  Data were derived from the longitudinal German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Incidence was calculated according to the ‘person‐years‐at‐risk’ method. Risk factors were analysed using multivariate logistic regression models. Results:  During the 3‐year follow‐up period, 350 (15.0%) of the 2331 patients whose data were included in the calculation of incidence developed MCI [person‐years (PY) = 6198.20]. The overall incidence of MCI was 56.5 (95% confidence interval = 50.7–62.7) per 1000 PY. Older age, vascular diseases, the apoE ε4 allele and subjective memory complaints were identified as significant risk factors for future MCI. Conclusion:  Mild cognitive impairment is frequent in older GP patients. Subjective memory complaints predict incident MCI. Especially vascular risk factors provide the opportunity of preventive approaches.