Toxic effects of chromatographic fractions of Phyllanthus amarus on the serum biochemistry of rats

Chromatographic fractions obtained from Phyllanthus amarus were tested for toxicity on the serum biochemistry of rats. The results revealed that some fractions of P. amarus had potentially deleterious effects on the blood and therefore caution should be exercised in the use of P. amarus as a medicin...

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Bibliographic Details
Published in:Phytotherapy research 2005-09, Vol.19 (9), p.812-815
Main Authors: Adedapo, A.A, Obatan, M.O, Idowu, S.O, Olorunsogo, O.O
Format: Article
Language:English
Subjects:
Administration, Oral
Alanine Transaminase - blood
Alanine Transaminase - drug effects
Animals
Aspartate Aminotransferases - blood
Aspartate Aminotransferases - drug effects
Biological and medical sciences
Blood Chemical Analysis
chromatography
Dose-Response Relationship, Drug
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phyllanthus
Phyllanthus amarus
Phytotherapy
Plant Extracts - toxicity
Plant Leaves
Rats
Serum Albumin - drug effects
serum biochemistry
toxicity
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Summary:Chromatographic fractions obtained from Phyllanthus amarus were tested for toxicity on the serum biochemistry of rats. The results revealed that some fractions of P. amarus had potentially deleterious effects on the blood and therefore caution should be exercised in the use of P. amarus as a medicinal plant. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1721